Abstract: Genetic sequencing of HBV showed the mutants of S143T, D144G, and G145R in the S gene region, and the mutant of site 1896 in the pre-Core region coexisted with the wild type (G1896A/G).
Result: Mutation analysis of this patient's HBV showed there were three mutants (S143T, D144G, and G145R) in the S gene region, and the mutant of site 1896 in the pre-Core region coexisted with the wild type (G1896A/G), but no mutation in the pre-S1, pre-S2, and
Occult and active hepatitis B virus detection in donated blood in Sao Paulo, Brazil.
Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).
Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, PMID: 31682960
2020
International journal of infectious diseases
Discussion: Many studies (Protzer-Knolle et al.,; Beckebaum et al.,; Cheung et al.,) have demonstrated that M133T itself is frequently associated with occult HBV infection and is also often associated with some mutations in the 'a' determinant such as G130N, F134L, D144A, D144G, G145A, G145K, and G145R or failed hepatitis B immune globulin (HBIG) prophylaxis.
Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Result: Consistent with our previous report, virion secretion was impaired by the T114R, T115A, K141E, and D144G immune escape mutations introduced into the 0.7mer construct.
Result: However, ELISA using a commercial kit (KHB, Shanghai, China) revealed less dramatic reduction of HBsAg titer in culture supernatant for these mutants, especially the D144G mutant.
Result: The K141E, D144G, and G145R mutants showed little or mild reduction in HBsAg secretion despite near loss of virion secretion.
Result: The M133T mutation could improve virion secretion of T114R
A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.
Discussion: In Latin America, the escape mutant D144A/G was characterized in a vaccinated child and potential escape mutants were identified in HBsAg+/anti-HBs+ patients in Argentina.
Discussion: Moreover, there are other reported escape mutants (P120T, T126A/S, and D144A/G) responsible for the evasion of vaccine-induced antibodies and therefore cause HBV infection in vaccinated individuals.
Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.
PMID: 25320728
2014
Clinical and molecular hepatology
Discussion: A mixture of D144G/D144A or combined D144E / G145R mutations were detected after hepatitis B immune globulin treatment.
Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants.
PMID: 23296324
2013
Human vaccines & immunotherapeutics
Abstract: HBsAg resulted undetectable by 3 of the 8 samples, derived from patients with multiple mutations: T126I-T131A-C139Y-E/D144G, T126I-M133L, and P120Q-T126I.
HBV mutation literature information.
PMID: 
2022
Frontiers in microbiology
Browser Board
Co-occurred Entities
Filtrator
ViMRT