Discussion: In this study, two mutations were found in the HNF1 Site (
K118E/I and
D119N) which were more prevalent in
HCC (37%) patients as compared to
LC (14.2%) and
CH (12%).
Discussion: Moreover, double combinational mutation (
K118E/I,
D119N) within regulatory elements of Enh-II has been shown to affect the replication of
HBcAg in situ and can manifest
liver disease.
HBV mutation literature information.
PMID: 
2022
PloS one
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