Abstract: Only mutations
C85R,
L87R,
L88R, and
C90R within TMD2 were associated with defective
HBsAg production.
Result: Particularly, no
HBsAg was detected in the supernatants of cultures transfected with mutants
L87R and
C90R.
Result: Seven
OBI-specific substitutions introducing an arginine residue in
S TMDs were investigated:
Q16R in TMD1,
C85R,
L87R,
L88R, and
C90R in TMD2, and
Q181R and