Introduction: Mutations at T53C, PreS deletions, PreS2 start codon, C7A, A2962G, C2964A and C3116T in the PreS region have been proved that significantly increase risk of HCC.
PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh.
PMID: 31952213
2020
International journal of molecular sciences
Abstract: Clinically significant mutations, such as preS1 C2964A, reverse transcriptase domain I91L, and small HBsAg N3S, were identified.
Conclusion: preS1 C2964A, RT domain I91L, and small HBsAg Result: Mutational analysis at the nucleotide level showed only two mutations, C2964A and C3062T, in the preS1 region of BD2 HBV; no mutations were found in the preS2 region, consistent with previous findings (Figure 2).
Molecular characterization of hepatitis B virus in Vietnam.
Method: The preS2/S1 sequences were analyzed for preS1 deletion, preS1 mutations (A2962G, C3026A/T, C2964A, and C3116T), preS2 start codon deletion, and preS2 mutations (T31C, T53C, A162G, and T531C/G).
Result: A2962G and C2964A mutations were identified in 99% (97/98) and 98% (96/98) of the genotype B isolates (Table 2).
Table: C2964A
Association between HBV Pre-S mutations and the intracellular HBV DNAs in HBsAg-positive hepatocellular carcinoma in China.
PMID: 25501679
2015
Clinical and experimental medicine
Abstract: Three Pre-S mutants (A2962G and C2964A in Pre-S1 and C105T in Pre-S2) were associated with higher tumor cccDNA levels (P < 0.05), and A2962G/C2964A mutants were associated with higher AFP levels.
Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.
Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C, PMID: 23166535
2012
Hepatitis monthly
Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurrence.
Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma.
Abstract: CONCLUSIONS: C2964A, C3116T, and C7A are novel markers independently associated with an increased risk of HCC, while A2964C and T3116C are novel markers independently associated with an increased risk of cirrhosis.
Abstract: Multivariate regression analyses showed that C2964A, C3116T, and C7A were novel factors associated with HCC compared with those without HCC, whereas A2964C and T3116C were independently as
HBV mutation literature information.
PMID: 
2022
PloS one
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