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 HBV mutation literature information.


  rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
 PMID: 33803998       2021       Microorganisms
Result: C-Q182K/* (C2444A/T or A2445G mutation), of which the frequency tended to be higher in rt269I strains than in rt269L strains (q = 0.068), has been reported to be significantly related to HCC in Korean chronic patients infected with genotype C2.
Result: We found a total of three types of signature NS mutations in the preC/C region (one in the preC region: preC-W28Stop, two in the C region: C-I97F/L ( PMID: 21785721       2011       Hepatitis research and treatment
Result: Further analysis of the nucleotide sequence at all three time points indicated that nucleotides T361A, C934A, C2351T/A2353T, and C2444T were the mutation been kept in for at least two years' evolution.
Result: These mutations caused nonsense mutation of preS1 and preCore/Core gene (T361A and C2444T, resp.), missense mutation of precore/core and pol gene (C2351T/A2353T and C934A, resp.).
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