Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Method: Mutations in the BCP (C1653T, T1674C/G, T1753 V, A1762T, G1764/A, C1766T, and T1768A) and the PC/core region (G1899A, C2002T, A2159G, A2189C, and G2203A/T) associated with HCC were also analyzed.
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Result: Meanwhile, the frequencies of hot-spot mutations in the C gene increased in the HCC group, from 6.1% (deletion), 15.2% (T1938C), 11.1% (C2002T), 13.1% (T2045A), 35.4% (A2159G), 40.4% (A2189Y), 10.1% (G2203W), and 22.2% (C2288R) in HCC cases to 2.0%, 7.1%, 7.1%, 14.3%, 20.4%, 22.4%, 2.0%, and 11.2% in controls, respectively.
Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.
Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C, PMID: 20699378
2010
Cancer epidemiology, biomarkers & prevention
Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T, A1762T, G1764A in the X gene, and G1899A, C2002T, A2159G, A2189C, and G2203W (A or T) in the pre-C/C gene, showed close associations with
HBV mutation literature information.
PMID: 
2020
Virology journal
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