Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.
Result: T1753A, A1761C, G1764T/A, C1766G/T, and C1773T mutations were detected in the BCP region.
Result: Of these, T1753A and A1761C mutations were detected in one sample (HB55); and G1764T/A, C1766G/T, and C1773T mutations were detected in two samples (HB35 and HB55).
The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infection.
Abstract: Mutations T1753C, A1762T, G1764A, C1766T, T1768A G1896A, G2092T and T2107C were associated with acute liver failure and progression to chronic hepatitis.
Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.
Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.
PMID: 30835025
2019
Digestive diseases and sciences
Abstract: Multivariate analysis showed that the independent factors for SAE were V14G/A and L21S in surface genes, codons 109-119 deletions in pre-S1 genes, M1V/T/I in pre-S2 genes, and C1766T/T1768A and C1913A/G mutations in BCP/PC genes.
Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Result: In the BCP region, the most common mutations were A1762T (30.0%, 8/26) and G1764T (30.0%, 8/26), followed by G1764A (26.0%, 7/26), C1766G (26.0%, 7/26), C1766T (11.5%, 3/26).
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Discussion: As the result of BCP polymorphism, clinically important multiple mutations per a study subject; such as T1753V/A1762T/G1764A and A1762T/G1764A/C1766T (or T1768A) were also the characteristics of the current study.
Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
Introduction: While A1762T/G1764A, C1653T, A799G, A987G, T1055A, pre-S deletion could be detected in the plasma long before PLC diagnosis, T1753C, C1766T and T1768A mutations appeared only one or two years before PLC diagnosis.,,These observations provide valuable information for HCC prediction and screening when using HBV mutations as the marker.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,
Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations.
Abstract: All the 12 HCC-associated SNVs proved by meta-analysis were confirmed by NGS analysis, except for C1766T and T1768A which were mainly expressed in genotypes A and D, but including the subgroup analysis of A1762T.
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Result: Among these clones, 13 (9 from HCC patients) harbored additional T1753C mutation (Fig. 1), 2 had additional C1766T mutation.
Result: In this regard 7 of the 12 highest replicating clones harbored either T1753C or C1766T.
Result: Our previous studies found that T1753C and C1766T could enhance the replication promoting effect of A1762T/G1764A hot spot mutations in genotype A.
HBV mutation literature information.
PMID: 
2022
PloS one
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