Result: C149R was not detectable by any of the three antibodies, suggesting a critical role of this cysteine residue in the expression of S antigens.
Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Result: By simultaneous detection of HBsAg in cell lysate and culture supernatant using this ELISA kit, we found that HBsAg secretion (as defined by ratio of cextracellular HBsAg/intracellular HBsAg) was severely impaired by the C138Y, R169L, R169P, and C149R mutations.
Discussion: The M133T mutation could efficiently rescue virion secretion of the I110M, T118K, G119E, P127S, G145R, and R169H mutants to nearly WT level, and moderately improve virion secretion of the
HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (
Epidemiology, risk factors and genotypes of HBV in HIV-infected patients in the northeast region of Colombia: high prevalence of occult hepatitis B and F3 subgenotype dominance.
Abstract: A C149R mutation, which may have resulted from failure in HBsAg detection, was found in one patient with OBI.
Result: There were three patients with four amino acid substitutions in the MHR (Q101H; C149R; L158G; G159R).
Table: C149R
Discussion: In a biological model, transfection of HBV genotype A clones in HepG2 cells revealed that the C149R mutation severely impaired HBV secretion in vitro.
Discussion: Mutations in the MHR (Q101H, C149R, L158G and G159R) were identified in three pati
HBV mutation literature information.
PMID: 
2020
PloS one
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