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 HBV mutation literature information.


  Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.
 PMID: 28874700       2017       Scientific reports
Abstract: C1485T-HBxTg mice were more susceptible to diethylnitrosamine-induced hepatocarcinogenesis than WT-HBxTg mice and control non-Tg mice.
Abstract: The promotion of hepatocarcinogenesis in C1485T-HBxTg mice was accompanied by the activation of beta-catenin and Jun N-terminal kinase (JNK) signaling pathways as well as the production of reactive oxygen species, whereas the activation of nuclear factor-kappa B in the livers of C1485T-HBxTg mice was attenuated.
Abstract: These results demonstrate that the HBx C1485T mutation contributes to human and murine hepatocarcinogenesis.


  Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
 PMID: 29287068       2017       PloS one
Discussion: C1485T, which is located in the RH domain overlapping with HBx, possesses RNase H activity that can degrade the pregenomic RNA template during minus-strand DNA elongation.
Discussion: Our previous study identified C1485T as a prognostic factor, which causes a critical amino acid change (Pro38Ser) in the X protein.


  The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.
 PMID: 25942596       2015       PloS one
Abstract: 3) Logistic regression showed that mutations A1383C (OR: 2.32, 95% CI: 1.34-4.01), R1479C/T (OR: 1.96, 95% CI: 1.05-3.64; OR: 5.15, 95% CI: 2.53-10.48), C1485T (OR: 2.40, 95% CI: 1.41-4.08), C1631T (OR: 4.09, 95% CI: 1.41-11.85), C1653T (OR: 2.58, 95% CI: 1.59-4.19), G1719T (OR: 2.11, 95% CI: 1.19-3.73), and T1800C (OR: 23.59, 95% CI: 2.25-247.65) were independent risk factors for genotype C HBV-related HCC, presenting different trends among individual disease phases.
Result: Five positions in HCC group (A1383C, R1479Y,


  [Associations between hepatitis B virus x gene mutations and hepatocellular carcinoma].
 PMID: 26447624       2015       Zhonghua gan zang bing za zhi
Abstract: RESULTS: Mutations of G1467C, G/C1479A, C1485T and C1653T in the X region were found, but did not show any significant difference in occurrence between the HCC group and the chronic HBV infection group (P>0.05).


  Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection.
 PMID: 21461076       2011       Gut and liver
Abstract: In addition, the T1753V (p<0.001) and C1485T (p<0.001) mutations were significantly more prevalent in HCC patients than in chronic hepatitis patients.
Abstract: RESULTS: Each of the mutations G1386M, C1485T, C1653T, T1753V, A1762T, and G1764A was significantly associated with the patient's clinical status.


  Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients.
 PMID: 22014121       2011       BMC cancer
Table: C1485T


  Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
 PMID: 19574418       2009       Journal of the National Cancer Institute
Table: C1485T



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