Abstract: Multivariate risk analysis confirmed that the
core mutations
A80V and
L116I were both independent predictors of HBV-associated liver disease progression.
Abstract: Six of the seven significant
core mutations that were identified in this study were located within immuno-active epitopes;
E77Q,
A80I/T/V, and
L116I were located within B-cell epitopes, and
F24Y,
E64D, and
V91S/T were located within T-cell epitopes.