literature

HBV mutation literature information.

[Risk factors analysis and a new risk scoring system predicting hepatocarcinogenesis for chronic genotype C HBV infected patients].

PMID: 30462954 2018 Zhonghua liu xing bing xue za zhi

Abstract: In genotype C HBV infected patients, male gender, aged 40 years and over, and four DNA mutations (T1674CG, A1762T/G1764A, A3120T, and A2962G) can increase the risk of HCC (P<0.05); interferon therapy can reduce the risk of HCC (P<0.05).

Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk.

PMID: 23516510 2013 PloS one

Abstract: In multivariate regression analyses, rs4938723 in dominant model increased HCC risk (AOR = 1.62, 95% CI = 1.05-2.49), whereas its multiplicative interaction with C1730G, a HBV mutation inversely associated with HCC risk, reduced HCC risk (AOR = 0.34, 95% CI = 0.15-0.81); rs11614913 strengthened the G1896A effect but attenuated the A3120G/T effect on HCC risk.

Result: In those with the data of HBV mutations in the preS region, pri-miR-34b/c rs4938723 in dominant genetic model was significantly associated with an increased risk of HCC whereas its int

Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.

PMID: 21104161 2010 Frontiers of medicine in China

Abstract: C2875A, G2950A, G2951A, A3054T, C3060T, T3066A, T3069G, A3120T, and G3191C were significantly associated with increased risks of HCC in genotype C, whereas these mutations were inversely associated with HCC in genotype B.

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