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 HBV mutation literature information.


  Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.
 PMID: 25881591       2015       Chinese medical journal
Abstract: The interaction of rs2299939 variant genotypes (GT+TT) with A3054T mutation significantly increased HCC risk (AOR = 2.41, 95% CI = 1.08-5.35); whereas its interaction with C3116T mutation significantly reduced HCC risk (AOR = 0.34, 95% CI = 0.18-0.66).
Result: Although the variant genotype of rs2299939 was significantly associated with a reduced risk of HCC, the interaction of rs2299939 variant genotypes with A3054T was significantly associated with an increased risk of HCC.
Result: There were significant interactions between PTEN polymorphisms and A3054T or C3116T, i


  Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma.
 PMID: 21104161       2010       Frontiers of medicine in China
Abstract: C2875A, G2950A, G2951A, A3054T, C3060T, T3066A, T3069G, A3120T, and G3191C were significantly associated with increased risks of HCC in genotype C, whereas these mutations were inversely associated with HCC in genotype B.



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