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 HBV mutation literature information.


  Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.
 PMID: 29065883       2017       Virology journal
Introduction: In addition, mutations such as T1753 V (genotype A, C or G), T1754S (genotype C or G), G1862 T, T1961 V, C1962D (A, G or T), and A2339G were more frequently found in fulminant hepatitis.


  Case-control study for the identification of virological factors associated with fulminant hepatitis B.
 PMID: 19456899       2009       Hepatology research
Abstract: RESULTS: Higher HBV DNA levels, subgenotype B1/Bj, A1762T/G1764A, G1896A, G1899A and A2339G mutation were significantly more frequent (P < 0.05), while hepatitis B e-antigen was less frequent in the FH-T patients than AHB.


  Molecular characterization of hepatitis B virus (HBV) isolates, including identification of a novel recombinant, in patients with acute HBV infection attending an Irish hospital.
 PMID: 18649329       2008       Journal of medical virology
Abstract: The latter also had a mutation, A2339G, in the core gene, not previously reported in severe acute infection caused by genotype D.


  Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene.
 PMID: 17498766       2007       Virology
Abstract: A HBV clone isolated from a patient with fulminant hepatitis was analyzed, and the features of the particular mutations observed around furin cleavage site in core region (A2339G/G2345A) were assessed using an in vitro replication model.
Abstract: In conclusion, the A2339G mutation was considered as one of the viral factors involved in high replication efficiency.
Abstract: Replication efficiency of 1.24-fold HBV genome in Huh-7 cells was increased in the presence of A2339G.



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