rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Result: Indeed, a previous study reported that C-I97F/L (A2189T/C or C2191T mutation) was the preC/C type found the most frequently in HCC patients in Korean chronic patients infected with genotype C2.
Result: We found a total of three types of signature NS mutations in the preC/C region (one in the preC region: preC-W28Stop, two in the C region: C-I97F/L (A2189T/C or
New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Result: As compared with non-ACLF cases, T216C, G285A, A1846T/G, G1896A, C1913A/G, A2159G/C, A2189T/C in genotype B and G285A, A1846T/G, G1896A, C1913A/G and A2159G/C in genotype C were significantly associated with an increased risk of ACLF(see Table 5).
Result: In ACLF patients with genotype B virus, the substitution rates of T216C,
HBV mutation literature information.
PMID: 
2021
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