rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Result: Indeed, a previous study reported that C-I97F/L (A2189T/C or C2191T mutation) was the preC/C type found the most frequently in HCC patients in Korean chronic patients infected with genotype C2.
Result: We found a total of three types of signature NS mutations in the preC/C region (one in the preC region: preC-W28Stop, two in the C region: C-I97F/L (A2189T/C or
Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Abstract: Clinical prognosis-related genetic variations such as nucleotide mutation T1762/A1764 (27.93%), A2189C (12.85%), G1613A (8.94%), T1753C (8.38%), T53C (4.47%) T3098C (1.68%) and PreS deletion (2.23%) were detected in CD recombinants.
Table: A2189C
Discussion: Other mutations, such as T53C, G1613A, C1653T, T1753C, A2189C, T3098C and PreS deletions were also reported associated with clinical progress.
Discussion: The same result was also found in frequencies of mut
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Result: Our unbiased approach led us to the discovery of additional variants highly associated with patient's HBeAg status: G1899A, A1838G, T2045A, G2345A, G2352A, T2441C, A2189C, T2443C, C1962A, G2237C, and others (LRT; p < 9.55 x 10-13.
Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.
Abstract: A series of novel PLC-related mutations including A2159G, A2189C and G2203W at the C gene, A799G, A987G and T1055A at the P gene of HBV genome were identified by using samples from the cohort.
Introduction: These mutations include A2159G, A2189C and G2203W at C gene, A799G, A987G and T1055A at P gene, and A1479T at X gene.
Molecular characterization of hepatitis B virus in Vietnam.
Method: Mutations in the BCP (C1653T, T1674C/G, T1753 V, A1762T, G1764/A, C1766T, and T1768A) and the PC/core region (G1899A, C2002T, A2159G, A2189C, and G2203A/T) associated with HCC were also analyzed.
Table: A2189C
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Discussion: demonstrated that A2189C and G2203W mutations were independent risk factors for HCC in another study from Qidong, showing odds ratios 3.99 and 9.70, respectively.
New point mutations in surface and core genes of hepatitis B virus associated with acute on chronic liver failure identified by complete genomic sequencing.
Abstract: The results of Illumina sequencing showed that the mutations at 7 sites (T216C, G285A, A1846T, G1896A, C1913A/G, A2159G, and A2189C) of 12 ACLF patients were significantly higher than those of 12 controls.
Result: As compared with non-ACLF cases, T216C, G285A, A1846T/G, G1896A, C1913A/G, A2159G/C, A2189T/C in genotype B and G285A, PMID: 25881591
2015
Chinese medical journal
Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C, PMID: 24788140
2014
PloS one
Introduction: In addition, A2159G and A2189C in the core gene and G1896A and G1899A in the pre-C gene have also been reported to increase the risk of HCC.
Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region, and A2159G
A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.
Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv
HBV mutation literature information.
PMID: 
2021
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