Abstract: The most common point-mutations included N/H51Y/T/S/Q/P (30.4%), V68T/S/I (44.9%), T/N87S/T/P (46.2%) on PreS1 gene; T125S/N/P (30.8%), I150T (42.5%) on PreS2 gene; S53L (37.7%), A184V/G (39.3%), S210K/N/R/S (39.3%) on S gene.
Result: The point-mutations on the S gene that owned the rates of >30% of the population were: S53L (37.7%), A184V/G (39.3%), and PMID: 28325923
2017
Emerging microbes & infections
Abstract: Moreover, the frequencies of mutations (L173P, Q181R and A184V) in cytotoxic T lymphocyte epitopes increased before entecavir treatment.
Result: As shown in Supplementary Figure S1, the frequencies of mutations (L173P, Q181R and A184V) in cytotoxic T lymphocyte (CTL) epitopes were increased before entecavir treatment, whereas mutations in the CTL domain aa 44-59 unexpectedly increased after entecavir treatment.
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
Result: Outside of the 'a' determinant, common mutations occurred at residues 164 (sE164G in 5/46 and sE164A in 1/46), 110 (sI110L in 5/46) and 184 (sA184V in 2/46).
Discussion: Additionally, two of our patients had sA184V, which was shown to impede detection by commercial assays of HBsAg in GTE infected Nigerian patients.
Analysis of HBV genotype, drug resistant mutations, and pre-core/basal core promoter mutations in Korean patients with acute hepatitis B.
Result: In the S gene, an A184V mutation was found in 17.9% of the cirrhotic and 24.6% HCC patients included in this study, respectively.
Discussion: However, the A184V mutation did not result in amino acid changes in the polymerase region.
Discussion: The S gene mutation, A184V, was detected in the ADV resistant rtA181T/V chronic hepatitis.
Discussion: There is one published report that the A184V mutation was related to reduced or negative HBsAg signal.
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
PMID: 20119580
2010
Journal of Korean medical science
Abstract: An S gene mutation, sA184V, was found in nine patients, all of whom were in group P.
Result: Among these mutations, only the W172stop/L173F (P<0.001) and A184V (P=0.002) mutation were significantly different between the groups (data not shown).
Result: Comparison of demographic, biochemical and clinical characteristics between patients with and without the sA184V mutation.
Result: In the S gene, an A184V mutation was found in 9 of 13 patients in Group P.
Result: Only the ALT level was significantly lower in patients with the sA184V mutation
Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S gene.
PMID: 17503077
2007
Medical microbiology and immunology
Abstract: DNA positive samples with no detectable HBsAg or reduced HBsAg detection signals (<75% of mean signal obtained with HBsAg positive samples) revealed several mutations (V14A, F46S, N48T, L49R, I49T, D51G, A53V, P54L, Q82P, F83C, L127P, A184V, T189I, S204N, V224A), mostly outside the a-determinant.
HBV mutation literature information.
PMID: 
2022
PloS one
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