literature

HBV mutation literature information.

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Table: A181V

Hepatitis B Virus Genotypes and Antiviral Resistance Mutations in Romanian HIV-HBV Co-Infected Patients.

PMID: 35454370 2022 Medicina (Kaunas, Lithuania)

Result: N236T: 28.8% and A181T/V: 15.5%:a profile suggestive for ADV resistance (and associated with reduced susceptibility to TDF/TAF).

Discussion: A relatively high prevalence of the N236T mutation was recorded in the study patients, which is frequently associated with the A181T/V mutation, a combination that confers decreased efficacy of tenofovir in vitro and was linked to a delayed response to TDF/TAF in patients with high viral loads, or with the compensatory L80V mutation, reported to be associated with LAM and ADV resistance.

Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.

PMID: 33571155 2021 Journal of infection in developing countries

Abstract: RESULTS: ETV-resistant mutants were continuously detected in 10 of the 12 patients, and multidrug-resistant (MDR) mutants, including a novel strain (rtL180M+A181V+T184A+S202G+M204V), were detected in two patients.

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Method: ETV resistance: Two or more amino acid substitutions are required across the HBV RT protein to confer resistance to ETV which could occur as a combination of M204I/V with one or more of the following substitutions L80I/V, I163V, I169T, V173L, L180M, A181S/T/V, T184X, A186T, S202C/G/I/R, M250I/V and/or C256S/G.

Method: For this analysis, we considered a total of 12 RAMs (S106C/G, D134E,

PMID: 33986897 2021 The Canadian journal of infectious diseases & medical microbiology

Result: RtM204I/V + rtL80I/V and rtM204I + rtA181 T/V may affect the sensitivity to LAM, TBV, and ADV; they also presented but the proportions of the mutations were low (Table 3).

Discussion: Furthermore, some pregnant women had multibase mutations combined with rtM204I/V at baseline, including rtM204I + rtA181 T/V, rtM204I/V + rtL80I/V,

PMID: 34007795 2021 Journal of clinical and translational hepatology

Table: A181V

COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.

PMID: 32708399 2020 Diagnostics (Basel, Switzerland)

Method: All sequences with completely replaced mt were further determined based on an HBV-drug resistance interpretation online tool of Max Planck Institute for Informatics for classical mt, e.g., rtL180M, rtA181V/T, rtT184G/L, rtA194T, rtS202I/G, rtM204I/V, rtN236T, and rtM250I/V, and based on updated references for nonclassical/putative mt, e.g., V207I/M/L,

Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.

PMID: 32765014 2020 Infection and drug resistance

Abstract: Primary and secondary DR variants were found in 7.3% (15/206) of patients, including rtL80I/V, rtI169T, rtV173L rtL180M, rtA181T/V, rtM204I/V, and rtN236T.

Result: Primary and/or secondary DR variants were found in 7.3% (15/206) of patients, and included rtL80I/V, rtI169T, rt

PMID: 32994690 2020 World journal of gastroenterology

Introduction: Classical primary resistance mutations include rtM204I/V (LAM-r) for LAM (rtM204I also confers resistance to LdT), rtA181V/rtN236T for ADV as well as LAM-r along with at least one substitution at rt184 (A/C/F/G/I/L/M/S), rt202 (C/G/I), and rtM250 (I/L/V) for ETV.

Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.

PMID: 33124952 2020 Emerging microbes & infections

Abstract: rtV191I and rtA181T/V were the only resistance mutations identified as genotype-specific mutation.

Result: After scrutinizing the frequency of mutations within these sites, only two NA-r mutations, ntG700A (rtV191I, P = 0.014) and ntC671T (rtA181T/V, P = 0.048) from treatment-naive and post-treatment samples, respectively, were identified as genotype-specific mutations (Figure 3(C-D)).

Result: Five AA sites identified with the significantly elevated entropy levels were rtL180M, rt

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