Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: For example, using direct sequencing of samples from treatment-naive patients from the United States, Nguyen et al demonstrated that only four (0.9%) of 472 patients were infected with viruses with primary and secondary mutations (rtA181A/S, rtA194S, and rtM250I).
Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients.
Abstract: Breakthrough hepatitis occurred in three patients without complete viral response and with poor response to the preceding LAM monotherapy, and rtA181A/V substitution was detected in one of the three patients.
Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naive patients with chronic hepatitis B.
HBV mutation literature information.
PMID: 
2018
World journal of gastroenterology
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