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 HBV mutation literature information.


  Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
 PMID: 33468062       2021       BMC infectious diseases
Table: A1775G


  [Clinical significance and mutation characteristics in the core promoter/pre-C region of different HBV genotypes in children].
 PMID: 32911905       2020       Zhonghua gan zang bing za zhi
Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.


  The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
 PMID: 29628773       2018       Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,


  Novel HBV mutations and their value in predicting efficacy of conventional interferon.
 PMID: 28381384       2017       Hepatobiliary & pancreatic diseases international
Abstract: CONCLUSIONS: PC-P159T (ntC2288A), BCP-N118T (ntA1726C), BCP-L134L (ntA1775C/G/T), PC-G182C (ntG2357T) and PC-S64A/T (ntT2003G/A) were novel identified mutations that impacted IFN therapeutic efficacy.
Abstract: Multivariate logistic regression analysis showed that baseline DNA, PC-P159T (ntC2288A),


  Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
 PMID: 25741368       2015       Hepatitis monthly
Abstract: In addition, G1721A/A1775G/T1858C combined mutation was associated with higher viral load and lower age distribution.
Abstract: Several combined mutations were obviously highly distributed in children with chronic HBV genotype C infection, such as G1721A/A1775G/T1858C triple mutation; a novel combined mutation type, exclusively detected in children with chronic HBV genotype C infection.
Result: Combined mutation characteristics were also found in other hotspot mutation positions from genotype C sequences of children, such as G1721A (G1721A/A1775G


  [Relationship between hepatitis B virus genotype, BCP/Pre-C region mutations and risk of hepatocellular carcinoma in Guangxi Zhuang Autonomous Region].
 PMID: 26564702       2015       Zhonghua liu xing bing xue za zhi
Abstract: A1775G is the protective factor in the development of HCC (OR = 0.192, 95% CI: 0.059-0.622, P = 0.006).
Abstract: CONCLUSION: The present investigation showed that BCP A1762T/G1764A, A1775G and Pre-C T1858C mutations are correlated with the incidence of HCC in Fusui county of Guangxi.
Abstract: The mutation rate of A1775G was significantly higher in control group (28.6%) than in HCC group (13.2%) (P = 0.041).


  Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children.
 PMID: 15240859       2004       Pediatric research
Abstract: Higher frequency of A1775G and G1799C mutation rates and lower frequency of A1752G mutation rate were found in the seroconverters.



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