Abstract: rs1234220 C allele was significantly associated with increased frequencies of HCC-risk A1652G, C1673T, and C1730G mutations in genotype B HBV-infected subjects.
Result: It was found that the variant genotype (TC) of rs1234220 was significantly associated with increased frequencies of HBV mutations A1652G (AOR = 4.16, 95% CI = 1.64-10.55), C1673T (AOR = 2.40, 95% CI = 1.02-5.66), and C1730G (AOR = 2.34, 95% CI = 1.02-5.39) in genotype B HBV-infected subjects.
Discussion: It is reasonable to speculate that rs1234220 variant genotypes increase HCC risk,
[Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma].
PMID: 24518026
2013
Zhonghua liu xing bing xue za zhi
Abstract: The interaction of rs2279776 GC genotype with G1896A could reduce the risk of HCC in HBV genotype B infected subjects and the interaction of CC genotype with A1652G significantly reduced the risk of HCC in HBV genotype C infected subjects.
Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.
Abstract: Special attention should be paid to A1703T, T1678C/G-A1703T, and A1652G-A1679G mutations probably specific of Tunisians sequences; they were observed in 40.6%, 41.5% and 30.1% respectively.
HBV mutation literature information.
PMID: 
2015
Chinese medical journal
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