Analysis of Hepatitis B virus (HBV) mutations in patients from Western Saudi Arabia with chronic disease.
PMID: 31954005
2018
Journal of infection in developing countries
Abstract: Mutations at preS1-A2922C, X-A1624C and PC-G1887A were detected only in cases with either a high fibrosis score or hepatocellular carcinoma (HCC), while mutations at positions PC-C1982A, PC-G1951T, X-C1628T and X-A1630G were detected more frequently in HCC cases, without reaching statistical significance.
Associations between serum HBX quasispecies and their integration in hepatocellular carcinoma.
PMID: 31966550
2017
International journal of clinical and experimental pathology
Abstract: In these, the HBX-integrated groups had significantly higher mutation frequencies at C1497T, A1630G, G1721A, A1762T/G1764A and A1774G.
HBx mutants differentially affect the activation of hypoxia-inducible factor-1alpha in hepatocellular carcinoma.
Result: It was particularly interested to find that mutants A1630G and G1721A always appeared concurrently and that mutant A1762T constantly accompanied mutant G1764A.
Result: Of the double mutations A1630G/G1721A, the mutation G1721A does not lead to the alteration of HBx codon, and thus the double mutations affect only the codon 86 of the X protein (H86Y).
HBV mutation literature information.
PMID: 
2018
Journal of infection in developing countries
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