literature

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S, sM133I/L/T, sC137W/Y, sG145A/R, and sA159G/V.

Result: In contrast, the detection rate of

PMID: 31269905 2019 BMC infectious diseases

Table: A159V/G

Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.

PMID: 27182775 2016 PloS one

Table: A159G

Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.

PMID: 27882070 2016 Hepatitis monthly

Abstract: Mutations in the S region of HBV DNA included S114T, G119R, P120S, T125M, C139Y, T140I, C147W, T148A, A159V/G, E164D, V168A, and R169C.

Result: Variants were found in 30.4% (21/69) of cases with OBI and included S114T, G119R, P120S, T125M, C139Y, T140I,

Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.

PMID: 24302857 2013 TheScientificWorldJournal

Result: In one case, A159G and R160K amino acid changes were found, and in the other, I68T amino acid substitution was observed.

Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication.

PMID: 19812261 2010 The Journal of general virology

Abstract: DNA immunization in BALB/c mice revealed that wtHBsAg and vtHBsAg with T123N and K160N are able to induce antibodies to HBsAg (anti-HBs), whereas

Abstract: Detection of HBsAg by ELISA and immunofluorescence staining indicated that variant HBsAg (vtHBsAg) with K122I was not recognized by HBsAg immunoassays, while vtHBsAg with T123N, A159G, K160N and A159G/K160N had reduced antigenicity.

"Molecular analysis of hepatitis B virus ""a"" determinant in asymptomatic and symptomatic Mexican carriers."

PMID: 17217533 2007 Virology journal

Result: T113S, S114T, R122K, I126T and P127L were the most frequent in both asymptomatic and symptomatic patients; whereas A159G, R160K, F161Y and V168A were more frequent in symptomatic patients.

Table: A159G