Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients.
Discussion: Interestingly, the wt-HBs sequence (F134) was mutated to F134Y after orthopedic liver transplantation (OLT) or mutants I134F or Y134F were reverted to the wt (F134) after OLT and the predicted antigenic index was made slightly more positive due to amino acid substitution at this position either by tyrosine or isoleucine.
Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt.
PMID: 27055927
2016
Arab journal of gastroenterology
Abstract: The first loop comprised four patients with three mutations (P127S, P127T and Y134F).
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
1Abstract: There were 14 mutations found in 5 patients; 6 were in the major hydrophilic region, of which 4 were Y134F assigning for the ""a"" determinant region."
Abstract: All patients who acquired Y134F contained S207R (within HLA-A2-restricted CTL epitope) as a combination.
Subgenotypes and mutations in the s and polymerase genes of hepatitis B virus carriers in the West Bank, palestine.
Discussion: It is probably that an unrecognized antibody response of the patients against their own HBsAg had exerted some selective pressure in favor of classical escape mutants and mutations to an amino acid associated with another genotype like Y134F and S143T.
Discussion: The amino acid exchange Y134F found in two patients correlated either with the HBsAg genotype A/adw2 or genotype D/ayw2.
HBV mutation literature information.
PMID: 
2019
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