Discussion: These included ps1F25L, ps1I48V, ps1V88L/A in the pre-S1 region, ps2M1I, ps2Q10R, ps2R48K/T, ps2A53V in the pre-S2 and sY100C, sP120T/A, sQ129R/H, s<
Mutations associated with occult hepatitis B virus infection result in decreased surface antigen expression in vitro.
Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1), T131I (n = 4), M133L/T (n = 18), G144E (n = 1) and G145A/R (n = 4).
Expression of Hepatitis B Virus Surface Antigen Containing Y100C Variant Frequently Detected in Occult HBV Infection.
PMID: 21331286
2011
Hepatitis research and treatment
Method: The other has a unique Y100C variation in its amino acid sequence.
Result: HBsAg levels of medium and cells extracts of pcDNA3-SA1 and pcDNA3-Y100C constructs, tested in three independent transf
Result: Nucleotide sequencing of HBV S gene inserted in recombinant expression plasmids pcDNA3-SA1 and pcDNA3-Y100C had confirmed the high similarity between both sequences.
Result: Overall, the mean values of extracellular HBsAg of pcDNA3-Y100C plasmid were 1.5-fold higher than those observed when the wild-type plasmid was transfected.
Result: The difference between the amount of HBsAg produced by pcDNA3-SA1 and pcDNA3-Y100C was not significant (P = .13).
Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.
PMID: 20382061
2010
International journal of infectious diseases
Abstract: In the NUC therapy group the prevalence was 8.5% (12/142), with the following patterns: sY100C+sI110V, sL109I, sP120T, sP127T, sG130R+sG145X, sS132A+sY134N, sY134N+sG145R, s
Occult hepatitis B virus infection and lamivudine-resistant mutations in isolates from renal patients undergoing hemodialysis.
PMID: 19817965
2010
Journal of gastroenterology and hepatology
Abstract: Four of these six HBV isolates contained mutations associated with lamivudine resistance in the DNA polymerase (two with L180M/M204V and two with rt173V/180M/204V) and a specific substitution (Y100C) in the HBV small surface protein.
Occult hepatitis B infection: an evolutionary scenario.
Result: Three HBV genotype A isolates (358-S; 312-SE; 161-CW) were shown to harbor tyrosine to cysteine substitutions in determinant a residue 100 (Y100C), and the T118V-A128V double mutant was found in three genotype D isolates (Table 2).
Table: Y100C
Discussion: The deduced amino acid sequence of the S gene product also revealed three isolates bearing the determinant a substitution Y100C, which is associated with the HBsAg-negative/anti-HBc-positive phenotype in blood donors from Venezuela and has been found in an HBsAg-positive Brazilian patient.
Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine.
HBV mutation literature information.
PMID: 
2012
PloS one
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