Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
Discussion: Accordingly, we did not find any antigenic or secretory defect arising from the mutation at amino acid position 100 (Y100C), either when present singly (C100Y) or together with other mutations (VDCR98-101LDYQ), although Motta-Castro et al.
Discussion: They also found reduced reactivity of HBsAg mutated at two positions simultaneously (Y100C/P120T).
Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China.
Abstract: Furthermore, the mutations sY100C, sQ101R/K, sS114A, sP120T, sT/I126A/N/S, sQ129R, sM133L/T/S and sG145R/A were prevalent in at least one genotype, with a frequency higher than 1%, which indicated that these mutations were relatively common.
Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.
Abstract: Escape mutations associated with failure of diagnosis (Y100C, R122K and Q129H) and with vaccine escape (Q129R and T131N) were detected in varying frequencies in the population.
Table: Y100C
Discussion: There were three escape mutations identified which were previously associated with diagnostic failure (Y100C, R122K and Q129H) and two associated with vaccine escape (Q129H and T131N).
Overt and occult hepatitis B virus infection among treatment-naive HIV-infected patients in Brazil.
Abstract: Known mutants Y100C, P127T and P120A associated to Y134H and S143T and new S mutants, which may potentially affect HBsAg expression and secretion and anti-HBs binding, were detected in baseline sera persisting up to the end of 9 years follow-up.
Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.
Result: At least 4 different genotype/subgenotype unrelated aa mutations are observed: V96A (1/47; 2.13%), L98V (1/47; 2.13%), Y100C (1/47; 2.13%), and I1110L (3/47; 6.38%) (data not shown).
Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and Sao Paulo, Brazil.
Result: When the genes were analyzed together, 9 of the 34 samples had mutations in both genes, and we found the following combinations: sM133L + sI195T with rtL80F + rtT128P, sI195M with rtL180M + rtM204V, sP120T with rt
Discussion: sY100C has been reported in cases of occult hepatitis, however Mello et al.
HBV mutation literature information.
PMID: 
2018
PloS one
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