Discussion: We found mutations as Y100C/F, P120S/T, R122K, I126T/N/S, S132P, M133T/S/L/I, G145R (the vaccine escape mutant, 2%), Y200F/W and Y206H/F/C as same as that were reported from other studies (Hudu et al.
Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.
Discussion: As demonstrated by Mello et al., Y100C alone may not affect HBsAg production, secretion or HBsAg affinity by commercial serological assays, as for our samples.
Discussion: Overall, Y100C was the most frequent substitution, being present in 6/10 sequenced samples.
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
8Discussion: Mutations in the MHR and non-MHR in the S region, such as Y100C, Y103I, Q129H, T131I, M133L/S/T, F134L, T143M, G145R, and L175S, were found in this study, and could reduce the affinity of monoclonal antibodies for ""a"" epitopes by altering the structure of HBsAg protein, which may contribute to the failure of commercial reagents."
Abstract: Mutations were found in the S gene, including Y100C, Y103I, G145R, and L175
In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Introduction: Also, mutations may occur in association with either vaccine-induced immune-escape (P120T, K122R, T126S, Q129H, G130N, M133L, and M133T) or in relation to the patients with occult HBV infection (Y100C, C124R, C124Y, K141E, and D144A).
Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Discussion: The three IEMs identified in the present study (sY100C, sA128V, and
Discussion: This study detected three IEMs, sY100C, sA128V, and sM133T, similar to previous studies (Mello et al.,; Kwei et al.,; Cremer et al.,).
Discussion: who showed a reduction in HBsAg detection level by commercial ELISA kit, but without statistical significance, leading the authors to conclude that mutation sY100C alone did not play a role in reducing the HBsAg affinity of this commercial ELISA assay.
Molecular characterization of hepatitis B virus in blood donors in Botswana.
Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.
Abstract: All occult HBV infection-associated Y100C and common diagnostic and vaccine-escape-associated P120T, G145R, K122R, M133L, M133T, Q129H, G130N, and T126S mutations were reliably detected by the assay, which consistently detected the presence of HBsAg in all 179 samples including samples with 11 novel mutations.
Abstract: Frequency of occult HBV infection-associated Y100C mutations was also determined.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
HBV mutation literature information.
PMID: 
2022
PloS one
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