literature

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Abstract: On multivariable analysis, males (OR = 4.51, 95%CI 1.78-11.4, p = 0.001), age>=40 (OR = 5.5, 95%CI 2.06-14.68, p = 0.001), W4P/R/Y on PreS1 (OR = 11.56, 95%CI 1.99-67.05, p = 0.006) and 4 S point-mutations as: T47A/E/V/K (OR = 3.67, 95%CI 1.19-11.29, p = 0.023), P120S/T (OR = 3.38, 95%CI 1.09-10.49, p = 0.035), S174N (OR = 29.73, 95%CI 2.12-417.07, p = 0.012), P203R (OR = 8.45, 95%CI 1.43-50.06, p = 0.019) were associated with HCC.

Result: Among them, 4 point-mutations W4P/R/Y, S5L/T, A90T/S/G, and

PMID: 29434654 2018 Infectious agents and cancer

Result: Among them, the W4R, L30S and Q118R/Stop mutations were more prevalent in OBI-related HCC (Table 3).|m

Result: The different mutations detected were W4R, S5A/P/T, L30S, G35R, H51P/R, E54K, A60V, W77R/Stop, I84T, N98 K/T, G102R, Q118R/Stop, N123D and S124F/P.

Male-specific hepatitis B virus large surface protein variant W4P potentiates tumorigenicity and induces gender disparity.

PMID: 25645622 2015 Molecular cancer

Abstract: Recently, we reported a novel HCC-related W4P/R mutation in the large surface protein (LHB) of HBV genotype C, which was found exclusively in male HCC patients.

Method: Sequences encoding WT and variant LHBs were amplified from a patient with HBV carrier status and an HCC patient, which were proven without and with W4P/R m

Discussion: In an effort to determine HBV mutation types that contribute to gender disparity in HCC, we recently discovered the W4P/R mutation, which is found only in men, using a molecular epidemiological approach.

Male-specific W4P/R mutation in the pre-S1 region of hepatitis B virus, increasing the risk of progression of liver diseases in chronic patients.

PMID: 24025913 2013 Journal of clinical microbiology

Abstract: W4P/R mutants were found to be significantly related to severe liver diseases (hepatocellular carcinoma [HCC] and liver cirrhosis, 12.4% [19/153] of patients, versus Abstract: The W4P/R mutations may provide in part an explanation for the relatively high ratio of male to female incidence in HCC generation in South Korean chronic HBV patients.

Abstract: The novel HBV pre-S1 mutations, W4P/R, may be associated with disease severity in male patients chronically infected with HBV genotype C.