Abstract: On multivariable analysis, males (OR = 4.51, 95%CI 1.78-11.4, p = 0.001), age>=40 (OR = 5.5, 95%CI 2.06-14.68, p = 0.001), W4P/R/Y on PreS1 (OR = 11.56, 95%CI 1.99-67.05, p = 0.006) and 4 S point-mutations as: T47A/E/V/K (OR = 3.67, 95%CI 1.19-11.29, p = 0.023), P120S/T (OR = 3.38, 95%CI 1.09-10.49, p = 0.035), S174N (OR = 29.73, 95%CI 2.12-417.07, p = 0.012), P203R (OR = 8.45, 95%CI 1.43-50.06, p = 0.019) were associated with HCC.
Result: Among them, 4 point-mutations W4P/R/Y, S5L/T, A90T/S/G, and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region.
PMID: 29563753
2018
World journal of gastroenterology
Discussion: In conclusion, we created W4P TG mice that constitutively express the full HBV genome with the W4P mutation in preS1 in the present study.
Discussion: Our data showed significantly increased hepatomegaly, enhanced granule generation in liver tissue, higher HBsAg expression in the liver and serum, and higher serum ALT and IL-6 levels in W4P TG males compared to the values of these parameters in W4P TG females or littermate control groups.
Discussion: Our data using W4P TG mice indicate that this mutation likely contributes to sex disparity in the susceptibility to liver disease, including HCC, leading to increased HBV virion replicat
Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region.
Abstract: CDDO-me exerted cytotoxic activity against W4P-LHB-expressing NIH3T3 cells, HepG2 cells, and Huh7 cells, and induced apoptotic cell death in a dose-dependent manner, demonstrating its anti-cancer activity against HCC.
Abstract: Furthermore, -CDDO-me administration significantly suppressed tumor growth induced by W4P-LHB-expressing NIH3T3 cells in nude mice, confirming its anti-cancer activity.
Abstract: In addition, CDDO-me treatment resulted in decreased cell migration and colony formation in in vitro assays using W4P-LHB-NIH3T3, HepG2, or Huh7 cell lines, supporting its anti-cancer activity through STAT3 inhibition.
Abstract: Previously, we showed that hepatitis B virus (HBV) la
Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region.
Abstract: A critical role of interleukin (IL)-6 signaling in W4P-mediated tumorigenicity was tested by inhibition of Jak2.
Abstract: CONCLUSIONS: This study suggests that the W4P mutation during the natural course of chronic hepatitis B infection may contribute to HCC development, particularly in male patients, in an IL-6-dependent manner.
Abstract: IL-6 levels of HCC patients with the W4P variant were significantly higher than those of patients with WT LHB.
Abstract: IL-6, but not tumor necrosis factor-alpha, was elevated in male mice harboring W4P-induced tumor, and was reduced by estrogen.
Abstract: METHODS: liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region.
PMID: 24025913
2013
Journal of clinical microbiology
Abstract: W4P/R mutants were found to be significantly related to severe liver diseases (hepatocellular carcinoma [HCC] and Abstract: All of the W4P/R mutants were found in males only.
Abstract: The W4P/R mutations may provide in part an explanation for the relatively high ratio of male to female incidence in HCC generation in South Korean chronic HBV patients.
Abstract: The novel HBV pre-S1 mutations, W4P/R, may be associated with disease severity in male patients chronically infected with HBV genotype C.
HBV mutation literature information.
PMID: 
2022
PloS one
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