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 HBV mutation literature information.


  Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
 PMID: 22666402       2012       PloS one
Result: As observed in the baseline quasispecies, a significant portion of the 20 most frequent variants (highest average substitutio
Result: Four of these 8 stop codons affected RT positions associated with NA resistance (sW172* related to rtA181T, sW182* to rtV191I, sW196* to rtM204I, and sW199* to rtV207I), at frequencies of 0.20% to 0.30%, significantly higher than the artifactual error (0.03%).


  Long-term hepatitis B virus (HBV) response to lamivudine-containing highly active antiretroviral therapy in HIV-HBV co-infected patients in Thailand.
 PMID: 22860080       2012       PloS one
Result: This mutation led to the concomitant substitution of tryptophan to stop codon at position 196 (sW196stop) in the surface protein.


  Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.
 PMID: 16428891       2006       Intervirology
Abstract: Following lamivudine therapy, 14 of 57 (24.5%) patients developed 16 types of S-gene mutations (sP120S, sA128V, sS143L, sW182St., sT189I, sV190A, sS193L, sI195M, sW196L, sW196St., sS207R,


  Failure of the lamivudine-resistant rtM204I hepatitis B virus mutants to efficiently support hepatitis delta virus secretion.
 PMID: 15858045       2005       Journal of virology
Abstract: The major HBV lamivudine (LMV)-resistant mutations in the polymerase gene within the reverse transcriptase (rt) region at rtM204V or rtM204I are associated with changes in the overlapping envelope gene products, in particular, the gene encoding small envelope protein (s) at sI195M or sW196L/S/Stop.



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