Abstract: sW182* and sL216* were recurrently found in the 25 HBcAg (-) HCC tumor tissue, too.
Abstract: Functional studies of the above 3 non-sense mutations all demonstrated higher cell proliferation activities and transformation abilities than wild type S, especially sW182*.
Abstract: Three nonsense mutations of S gene (sL95*, sW182*, and sL216*) were identified in the HBcAg
Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naive and lamivudine-treated patients with chronic hepatitis B.
Abstract: With little influence on immune escape-associated mutation frequencies within 'a' determinant, LMV-monotherapy significantly induced classical LMVr-associated mirror changes sE164D/rtV173L, sI195M/rtM204V and sW196L/S/rtM204I, as well as non-classical ones sG44E/rtS53N, sT47K/A/rt
Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma.
Introduction: The two types of mutations related to clinical severity, the F141L preS2 mutation and W182* leading to premature termination in the HBV surface antigen (HBsAg), were recently noted in Korean chronic patients.
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
Result: As observed in the baseline quasispecies, a significant portion of the 20 most frequent variants (highest average substitution frequencies in the 5 samples) led to stop codons (sW156*, sW172*, sW182*, sW191*, sW196* and sW199*), especially at LMV VBK and at the end of ADV, mainly due to mutation sW172*, related to rtA181T, (71.7% and 64%, respectively) and sW182*, rela
Nucleotide change of codon 182 in the surface gene of hepatitis B virus genotype C leading to truncated surface protein is associated with progression of liver diseases.
Abstract: CONCLUSIONS: In the present study, we demonstrate that the sW182* of HBV could provide an important contribution to the progression of liver diseases, through molecular epidemiologic and in vitro studies.
Abstract: In addition, an in vitro study using cell lines stable expressing the S protein with sW182* also strongly supported its relationship with HCC.
Abstract: In this study, novel nucleotide changes (sW182*) that result in a premature stop at codon 182 in the S gene of genotype C are investigated with regards to the development of HCC
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
PMID: 20119580
2010
Journal of Korean medical science
Result: Similarly, in Group P, there was one case of each of the following mutations: F41C, A45V, P49L, Q54L, P62L, I92T, L98V, T140S, A157V, W182stop, and S204R.
Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.
HBV mutation literature information.
PMID: 
2014
PloS one
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