Abstract: CONCLUSIONS: Our findings suggest that the decrease in viral population heterogeneity at an early stage of LdT treatment was associated with the subsequent optimal virological response, and the early appearance of some specific mutations, such as sG44E, sW172* and sW182*, is a potential indicator of a partial virological response in continuing therapy.
Abstract: RESULTS: Sequencing results revealed different dynamics of non-synonymous mutations, such as sL9P, sN40S, sG44E, sW172*, PMID: 27650283
2017
Journal of hepatology
Result: revealed previously identified immune escape mutations within the 'a' determinant region (sS117T, sK122R, sI126N/S/T, and sG145R), carboxyl terminal truncation mutations (sC69* and sW182*) and additional rarely described mutations (sE2G, sL21S, sR24K, sT47K/A
Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis.
Abstract: Cell lines were transfected with infectious HBV clones encoding surface stop codons rtM204I/sW196*, rtA181T/sW172*, rtV191I/sW182*, and a panel of substitutions in the surface proteins.
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Discussion: More distal nonsense mutations in the S region include W172*, W182*, W201*, and L209*.
Discussion: On the other hand, HBsAg secretion (the ratio of extracellular HBsAg/intracellular HBsAg) was completely blocked by the L209* mutation and diminished by the W182* and W201* mutations.
Discussion: We found the L209*, W182*, and especially W201* mutations markedly reduced intracellular S protein and HBsAg.
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: The most frequently identified HBsAg amino acid substitutions in previous studies include P120T, M33I, S143L, D144E/A, G145R, E164D, W172*, and W182* which are the most commonly occurring pattern.
Nucleos(t)ide analogues causes HBV S gene mutations and carcinogenesis.
PMID: 27919846
2016
Hepatobiliary & pancreatic diseases international
1Abstract: DATA SOURCES: PubMed and Web of Science were searched using terms: ""hepatitis B virus"", ""HBV drug resistance mutation"", ""HBV surface protein"", ""HBV truncation"", ""hepatocellular carcinoma"", ""rtA181T/sW172*"", ""rtM204I/sW196*"", ""rtV191I/sW182*"", and relevant articles published in English in the past decades were reviewed."
Abstract: RESULTS: The rtA181T/s
Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation.
Abstract: Mutation analysis in the S gene demonstrated two significant mutations which were W182 stop codon and deletion at open reading frame (ORF) of pre-S1 with the frequency occurrence of 2.2% (2/93) and 5.4% (5/93), respectively.
Abstract: The two patients with W182 stop codon were both male, infected with HBV genotype C and one showed progression of liver disease to hepatocellular carcinoma (HCC).
Result: Case Report of W182 Stop Codon Mutation.
Result: The characteristics of the two patients with W182* mutation were summarized in Table 3.
Abstract: A gene expression microarray in combination with gene set enrichment analysis (GSEA) revealed differentially expressed gene sets in the sW182* cells, including those related to cell-cycle regulation, deoxyribonucleic acid repair, and genome instability.
Abstract: Among them, the sW182* mutant (the stop codon for tryptophan 182) showed the most potent oncogenicity in a mouse xenograft model using stably transfected mouse fibroblast cells.
Abstract: Exogenous expression of TGFBI alleviated the oncogenic activity of the sW182* cells.
Abstract: Of the differentially expressed genes, the transforming growth factor-beta-induced (TGFBI) gene was further validated to be dysregulated in the sW182*
Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
Result: Additionally, two premature stop codon mutations, the C69* and the W182* mutation, were observed outside the MHL region in two isolates.
Discussion: Finally, this study for the first time also reports the presence of the -1 G frameshift deletion and the W182* mutations among the Indian population but with a lower frequency.
Discussion: The W182* mutation had been previously reported to have severe clinical implications.
HBV mutation literature information.
PMID: 
2017
Antiviral therapy
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