Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Abstract: BACKGROUND: Development of the hepatitis B virus (HBV) rtA181T/sW172* mutant could occur during prolonged lamivudine (LAM) therapy, conferring cross resistance to adefovir.
Abstract: CONCLUSIONS: Emergence of the rtA181T/sW172* mutant in LAM-resistant patients increased the risk of HCC development in the subsequent courses of antiviral therapy.
Introduction: Because of the overlap between the S and polymerase genes, a great proportion of patients carrying the rtA181T mutation also possessed the
Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B.
PMID: 21784687
2011
International journal of infectious diseases
Abstract: RESULTS: Seven types of ADAPVEM were detected in the total CHB patients: rtM204V/sI195M, rtM204I/sW196S, rtM204I/sW196L, rtV173L/sE164D, rtA181T/sW172*, rtA181T/
National survey of hepatitis B virus (HBV) polymorphism in asymptomatic HBV blood donors from 1999 to 2007 in France.
Abstract: rtA181T/sW172 stop mutation associated with resistance to nucleos(t)ide analogs was detected in two donors suggesting a transmission of these isolates.
Development of HBV S gene mutants in chronic hepatitis B patients receiving nucleotide/nucleoside analogue therapy.
Abstract: Among them, the rtA181T/sW172* mutant has a dominant negative secretion effect as well as an increased oncogenic potential.
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
PMID: 20119580
2010
Journal of Korean medical science
Discussion: A large percentage of the cases with rtA181T mutations developed sW172stop mutations.
Discussion: We detected sW172stop and sL173F mutations in 10 of the 13 patients with ADV-resistant rtA181T/V polymerase mutations.
Discussion: Whereas a domain D rtN236T mutation does not overlap with the envelope gene, a mutation at rtA181T can result in a stop mutation in the envelope
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
PMID: 20119580
2010
Journal of Korean medical science
Abstract: Although sW172stop and sL173F mutations were detected, reduced HBsAg titer was not observed.
Result: AST (P=0.035) and ALT (P=0.009) levels were significantly lower in patients with W172stop/L173F mutation.
Result: Among the patients in Group P, sW172stop (n=5) and sL173F (n=5) mutations were detected.
Result: Among these mutations, only the W172stop/L173F (P<0.001) and A184V (P=0.002) mutation were significantly different between the groups (data not shown).
Result: Co
Identification of nonsense mutations in hepatitis B virus S gene in patients with hepatocellular carcinoma developed after lamivudine therapy.
Abstract: NIH3T3 cells stably expressing sL21*, sW156* and sW172* pre-S/S mutants had increased tumourigenicity in nude mice.
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Abstract: CONCLUSION: The rtA181T/sW172* variant has a secretory defect and exerts a dominant negative effect on wild-type HBV virion secretion.
Abstract: In vitro analysis revealed that the rtA181T/sW172* variant is not only defective in secretion of viral particles causing intracellular retention of surface proteins, it also has a dominant negative effect on virion but not subviral particle secretion when coexpressed with the wild type.
Abstract: The selection of rtA181T/sW172* reduced the typical extent of virological breakthrou
"Molecular analysis of hepatitis B virus ""a"" determinant in asymptomatic and symptomatic Mexican carriers."
HBV mutation literature information.
PMID: 
2011
BMC cancer
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