De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
PMID: 27079793
2016
Annals of clinical microbiology and antimicrobials
Result: Additionally, 1 clone and 15 clones harboring rtA181 T mutations in in patients 3 and 4, respectively, showed sW172* mutations.
Result: In patient 1, 3 clones harboring the rtA181 T mutation had sW172*(stop codon) mutations in the overlapping S gene.
Result: In this study, all genotype C HBV clones harboring the rtA181 T mutation had sW172* mutations in the overlapping S-gene.
Result: It has been reported that the rt
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
PMID: 26567840
2016
Japanese journal of infectious diseases
Abstract: HBsAg levels were significantly higher in both supernatant of cells transfected with HBV wt and serum of mice injected with HBV wt, compared with that of HBV rtA181T/sW172* mutant.
Abstract: Full-length HBV wild type (wt) and HBV rtA181T/sW172* expression plasmids were transfected into HepG2 cell lines or were injected into C57BL/6 mice.
Abstract: Furthermore, GRP78 mRNA expression was increased 72 h post-transfection in HBV rtA181T/sW172* cells relative to HBV wt cells (P = 0.0154).
Abstract: HBV
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: The most frequently identified HBsAg amino acid substitutions in previous studies include P120T, M33I, S143L, D144E/A, G145R, E164D, W172*, and W182* which are the most commonly occurring pattern.
Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients.
PMID: 27894395
2016
Cellular and molecular biology (Noisy-le-Grand, France)
Abstract: rtA181T mutation was accompanied with not only sW172 * mutation, but also sW172L mutation,
Abstract: Among 25 containing rtA181T/V mutation patients, 7 rtA181T mutation cases with sW172L, 6 rtA181T mutation cases with sW172*, 12 rtA181Vmutation cases with sL173F.
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Abstract: Combined analysis of complimentary DNA microarray and microRNA array identified microRNA-873-mediated reduced expression of the CUB and Sushi multiple domains 3 (CSMD3) protein, a putative tumor suppressor, in TgSW172* mice.
Abstract: Hepatitis B virus (HBV) carrying the rtA181T/sW172* mutation conferred cross-resistance to adefovir and lamivudine.
Abstract: Higher proportion of apoptotic cells was found in TgSW172*-H mice, accompanied by increased cyclin E levels, suggesting increased hepatocyte turnover.
Abstract: Molecular analysis of liver tissues revealed significantly increased expression of glucose-regulated protein 78 and phosphorylated extracellular signal-regulated kinases 1 in TgSW172* mice, and decreased expre
Nucleos(t)ide analogues causes HBV S gene mutations and carcinogenesis.
PMID: 27919846
2016
Hepatobiliary & pancreatic diseases international
1Abstract: DATA SOURCES: PubMed and Web of Science were searched using terms: ""hepatitis B virus"", ""HBV drug resistance mutation"", ""HBV surface protein"", ""HBV truncation"", ""hepatocellular carcinoma"", ""rtA181T/sW172*"", ""rtM204I/sW196*"", ""rtV191I/sW182*"", and relevant articles published in English in the past decades were reviewed."
Abstract: RESULTS: The rtA181T/s
Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems.
Abstract: Compared with wild-type strains, there were intracellular accumulations of HBsAg and HBcAg in rtA181/sW172* but none in rtA181/sW172L mutant strains.
Abstract: In animal experiments, we were amazed to find that viral replication in rtA181T/sW172* mutant increased and maintained significantly longer than that in rtA181T/sW172L mutant, while no significant difference was observed between rt
Composition and Interactions of Hepatitis B Virus Quasispecies Defined the Virological Response During Telbivudine Therapy.
Result: Hence, the rtA181T/sW172* mutants need the aid of coexisting wild-type quasispecies to provide a functional S protein for virion packaging.
Result: The rtA181T mutation also causes a stop-codon mutation in the overlapping surface protein (S protein) gene (Supplementary Table S3), i.e., sW172*, which causes a 55 amino acid-residue truncation in the S protein.
Discussion: Although packaging-deficient rtA181T/sW172* mutant
[Clinical emergence features and implications of hepatitis B virus rtA181T mutation].
Abstract: CONCLUSION: The HBV rtA181T mutation is closely associated with adefovir and lamivudine exposure.rtA181T may led to sW172*, culminating in suppression of HBsAg secretion.However, co-existence of the mutant with wild-type sequences was common among our patient population, suggesting that the mutation had little impact on serum HBsAg and HBV DNA levels across the clinical study population.
Abstract: METHODS: Serum samples from 3, 013 patients who visited The 302 Hospital (Beijing, China) were investigated.HBV DNA was extracted and HBV mutations and genotypes were determined by direct sequencing.Recombinant plasmids harboring the rtA181T/
Identification of transforming hepatitis B virus S gene nonsense mutations derived from freely replicative viruses in hepatocellular carcinoma.
Discussion: Among the 11 HBV S gene truncation mutants we have identified (sL15*, sL21*, sS61*, sC69*, sL95*, sW156*, sW163*, sW172*, sW182*, sW196*, and sL216*) in HBV-related
ViMRT
HBV mutation literature information.
PMID: 
2016
Annals of clinical microbiology and antimicrobials
