literature

HBV mutation literature information.

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Discussion: For example, RAMs in HBV reverse transcriptase, A181T/V, M204I and M204V, cause corresponding changes in the overlapping region of HBsAg (W172 stop, W196S/L/Stop and I195M, respectively).

Hepatitis B Virus preS/S Truncation Mutant rtM204I/sW196* Increases Carcinogenesis through Deregulated HIF1A, MGST2, and TGFbi.

PMID: 32887289 2020 International journal of molecular sciences

Abstract: Some of these mutants introduce premature stop codons in the overlapping surface (s) gene, including rtA181T/sW172*, which has been shown to enhance oncogenicity.

Introduction: We investigated four such mutants (sL15*, sL21*, sW156*, and sW172*) in our 3TC-experienced HCC cases for their nearby locations to the transactivity-on-region, and proved sL15*,

PMID: 32840739 2020 Virus genes

Abstract: The rtA181T mutation caused the W172* nonsense mutation in the overlapping S gene.

Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice.

PMID: 30866789 2019 Emerging microbes & infections

Discussion: Unlike rtA181 T mutation which may cause sW172stop and non-stop (sW172S, sW172L) mutations and the stop mutation will delete an HLA-A2-restricted s172-180 (env335-343) epitope of cytotoxic T lymphocytes (CTL) the rtA181C mutation only caused sW172C mutation in this study without deleting the CTL epitope.

Molecular cloning and phenotypic analysis of drug-resistance mutants with relevant S-region variants of HBV for a patient during 189-month anti-HBV treatment.

PMID: 30882363 2019 Antiviral therapy

Abstract: Interestingly, the rtA181T-causative sW172stop to sW172non-stop mutation transition was observed at HBV DNA fluctuations.

Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.

PMID: 30906435 2019 Experimental and therapeutic medicine

Result: Furthermore, three out of five stop codons in the S region (sS34*, sW74*, sW172*, s Discussion: Similar to previous studies, the present study suggested that truncation mutations (rtA181T/sW172*, rtM204I/sW196* and rtV191I/sW182*) occurred at the highest frequency.

Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.

PMID: 31189581 2019 Journal of clinical microbiology

Table: W172stop

The Effect of the Hepatitis B Virus Surface Protein Truncated sC69( *) Mutation on Viral Infectivity and the Host Innate Immune Response.

PMID: 31249567 2019 Frontiers in microbiology

Introduction: Recently, it was shown that HBsAg truncated mutants such as sW172*, sW182*, and sW199* occurred in patients both with and without antiviral treatment.

Introduction: Similarly, it was also shown that HBV WT rescued the replication and secretion of variants such as sW172*, sW182*, and sC69*.

Discussion: showed that sW172* mutant could be rescued by WT for secretion.

Complementation of Wild-Type and Drug-Resistant Hepatitis B Virus Genomes to Maintain Viral Replication and Rescue Virion Production under Nucleos(t)ide Analogs.

PMID: 31218588 2019 Virologica Sinica

Abstract: In the present study, HBV genomes with frequently detected reverse transcriptase (RT)/surface truncation MTs, rtA181T/sW172*, rtV191I/sW182* and rtM204I/sW196*, were phenotypically characterized alone or together with their WT counterparts in different ratios by transient transfection in the absence or presence of NAs.

Clinical and Virological Aspects of HBV Reactivation: A Focus on Acute Liver Failure.

PMID: 31527514 2019 Viruses

Result: A similar pattern was observed for the W172* mutant.

Result: Therefore, Huh7-cells were transiently transfected with a plasmid encoding the strep-tagged HBsAg, carrying the wild-type (wt) sequence and the SHB

Discussion: HBsAg stop codon mutations leading to a truncated HBsAg such as W172* have been described in patients with chronic hepatitis B patients in the past and have been associated with lamivudine/entecavir resistance, cirrhosis, and hepatocellular carcinoma, as well as defective HBsAg secretion like L216*.

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