Result: Because the entire S gene is embedded within the viral polymerase gene, some viral polymerase mutations that confer drug resistance can cause amino acid sequence changes in HBsAg; major ones include E164D, W172L, L173F, I195M and W196L/S/V.
Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice.
Discussion: Unlike rtA181 T mutation which may cause sW172stop and non-stop (sW172S, sW172L) mutations and the stop mutation will delete an HLA-A2-restricted s172-180 (env335-343) epitope of cytotoxic T lymphocytes (CTL) the rtA181C mutation only caused sW172C mutation in this study without deleting the CTL epitope.
The truncated mutant HBsAg expression increases the tumorigenesis of hepatitis B virus by regulating TGF-beta/Smad signaling pathway.
Introduction: In theory, its overlapping S gene should have two types of mutation at amino acid 172, which include rtA181T/sW172L (TGG CTC TTA CTC) mutant coding substituted HBsAg protein and rtA181T/sW172*(TGG C
Introduction: Our previously studies showed that the replication capacity of HBV rtA181T/sW172* mutant was higher than that of HBV rtA181T/sW172L mutant.
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Abstract: 3.69-fold in half maximal effective concentration of wild-type strain); rtA181T/sW172L + rtS202G + rtM204V strain exhibited higher HBV DNA production and entecavir resistance fold than that of rtA181T/sW172* + rtS202G + rtM204V strain (50.98% vs.
Abstract: rtA181T/sW172S +
Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants.
Result: The rtA181T substitution was mainly associated with an sW172* substitution, only 15.4% (4/26) had other missense mutations (three with sW172L, one with sW172S).
Discussion: They found the serum levels of HBV DNA and HBsAg in pHBV-rtA181T/sW172* injected mice were significantly lower than that of pHBV-rtA181T/sW172L injected mice.
Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients.
PMID: 27894395
2016
Cellular and molecular biology (Noisy-le-Grand, France)
Abstract: rtA181T mutation was accompanied with not only sW172 * mutation, but also sW172L mutation,
Abstract: Among 25 containing rtA181T/V mutation patients, 7 rtA181T mutation cases with sW172L, 6 rtA181T mutation cases with sW172*, 12 rtA181Vmutation cases with sL173F.
Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems.
Result: As compared to negative control pcDNA3.1 transfected cells, the relative luciferase activity of CpLUC increased 40% in pcDNA-HBs(sW172*) transfected cells; but no obvious change was observed in either pcDNA-HBs(wt) or pcDNA-HBs (sW172L) transfected cells.
Discussion: And this may explain the lower levels of HBV DNA in c
Discussion: As the sW172L and sW172* mutations of HBsAg gene are not inside the 'a' determinant, currently commercially antibody for substituted or truncated HBsAg is effective.
[Clinical emergence features and implications of hepatitis B virus rtA181T mutation].
Abstract: The rates of HBV/C to HBV/B were 92.1% to 7.9% in the rtA181T-positive patients, but 82.1% to 17.9% in the rtA181T-negative paticnts (P less than 0.01).Almost all (98.2%; 129/165) of the rtA181T led to sW172*, while only 1.8% of the rtA181T (3/165) led to sW172L or sW172S.HBsAg secretion in vitro was reduced from the rtA181T/ sW172*
Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B.
PMID: 21784687
2011
International journal of infectious diseases
Abstract: RESULTS: Seven types of ADAPVEM were detected in the total CHB patients: rtM204V/sI195M, rtM204I/sW196S, rtM204I/sW196L, rtV173L/sE164D, rtA181T/sW172*, rtA181T/
Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
PMID: 16982790
2006
Antimicrobial agents and chemotherapy
Abstract: The substitution also induced a unique amino acid substitution (W172L) in the overlapping hepatitis B surface (HBs) protein.
HBV mutation literature information.
PMID: 
2020
PloS one
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