Abstract: Drug-resistance mutations were present also in patients with undetectable serum HBV-DNA: M204I was detected in 2 patients receiving LAM-monotherapy, and V84M in 1 patient receiving LAM+ADV.
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.
Method: We also analyzed the mutations that have been reported to possibly contribute to resistance at 10 additional positions: L82M, V84M, S85A, A194T, A200V, V214A, Q215S, I233V, P237H and NASH238TD.
[Resistance to adefovir in patients with chronic hepatitis B].
PMID: 17237626
2006
The Korean journal of hepatology
Abstract: Other mutations in the HBV polymerase (rtP237H, rtN238T/D, rtV84M, rtS85A, rtV214A, rtQ215S) reduce sensitivity to adefovir, but the significance of these mutations is unclear.