HBV mutation literature information.


  Lamivudine-resistance mutations can be selected even at very low levels of hepatitis B viraemia.
 PMID: 20621632       2010       Digestive and liver disease
Abstract: Drug-resistance mutations were present also in patients with undetectable serum HBV-DNA: M204I was detected in 2 patients receiving LAM-monotherapy, and V84M in 1 patient receiving LAM+ADV.


  Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.
 PMID: 20875460       2010       Antiviral research
Method: We also analyzed the mutations that have been reported to possibly contribute to resistance at 10 additional positions: L82M, V84M, S85A, A194T, A200V, V214A, Q215S, I233V, P237H and NASH238TD.


  [Resistance to adefovir in patients with chronic hepatitis B].
 PMID: 17237626       2006       The Korean journal of hepatology
Abstract: Other mutations in the HBV polymerase (rtP237H, rtN238T/D, rtV84M, rtS85A, rtV214A, rtQ215S) reduce sensitivity to adefovir, but the significance of these mutations is unclear.



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