Abstract: All five mutation types (
V5M/L,
P38S,
H94Y,
I127T/N, and
K130M and
V131I) affecting the six codons were found to be related significantly to clinical severity.
Abstract: Among these, two mutation types (
V5M/L and
K130M and
V131I) were observed more frequently in
HBeAg negative patients than in
HBeAg positive patients.
Abstract: In particular, a novel mutation type (
V5M/L) discovered firstly during the present study was found to be associated significantly with
HCC.