PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh.
PMID: 31952213
2020
International journal of molecular sciences
Result: However, some mutations (H9Y, N13H, I91L, I269L, and V278I) were found in the RT domain that are not associated with drug resistance, according to Geno2pheno:hbv.
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
PMID: 31189581
2019
Journal of clinical microbiology
Table: V278I
Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.
Result: Although the frequency of amino acid substitutions were not significantly different, a total of 16 amino acid substitutions in the polymerase domain occurred only in tenofovir-experienced isolates compared to tenofovir-naive isolates, including S117Y, S117C, I121N, T128I, M129L, R138K, R138E, L140P, V142A, I163V, L217R, N238H, R242K, K270R, V278I, and R280S.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: At 48 week of TDF therapy, the frequencies of rtM204I, rtL80I, sS45A, sT118V, sW196L and sA128V continued to be significantly reduced from baseline in responders, although an increase in frequency of the substitution rtV278I was noted in the HBV clones of the responders during this observational period (Table 5).
Result: Out of the 17 aa substitutions where significant differences were observed in frequencies between HBV clones, 10 substitutions (rt
HBV mutation literature information.
PMID: 
2022
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