Abstract: Each amino-acid substitution appeared alone and included rtA194T, rtV214A, rtQ215S, rtI233V and rtN236T.
A sensitive direct sequencing assay based on nested PCR for the detection of HBV polymerase and surface glycoprotein mutations.
PMID: 19442845
2009
Journal of virological methods
Abstract: Direct sequencing was able to show pol mutations not revealed by DR v2, such as rtV214A, rtQ215H/S, and rtM250V.
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
PMID: 19222103
2009
World journal of gastroenterology
Abstract: These mutations were rtV214A/rtN238T in one patient and rtA194T in the other.
[Resistance to adefovir in patients with chronic hepatitis B].
PMID: 17237626
2006
The Korean journal of hepatology
Abstract: Other mutations in the HBV polymerase (rtP237H, rtN238T/D, rtV84M, rtS85A, rtV214A, rtQ215S) reduce sensitivity to adefovir, but the significance of these mutations is unclear.
Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.
Abstract: Four substitutions (rtS119A, rtH133L, rtV214A, and rtH234Q) developed once each at conserved sites in HBV polymerase in 4 ADV-treated patients.