Result: RT sequence changes implicated in adefovir-resistance were detected, including S213T 5.83% (19/325), S213N 0.9% (3/325), V214E 0.61% (2/325), V214A 0.61% (2/325), Q215P 2.75% (9/325), Q215S 7.06% (23/325), Q215H1.53% (5/325), and F221Y 2.76% (9/325) of isolations that previously reported adefovir-resistance mutation (Figure 1).
Table: V214A
Discussion: In addition, a number of other mutations have been detected in our study and were clustered into three distinct regions of the RT: the D and A domains (rtP237H, rt
Comparison of INNO-LIPA and TRUGENE assays for genotyping and drug-resistance mutations in chronic hepatitis B virus infection.
Abstract: In relation to drug-resistance mutations, the sensitivity of the line probe assay was lower than TRUGENE because INNO-LIPA could not detect two mutations (S202G and V214A).
[Clinical analysis of hepatitis B virus mutations related to adefovir dipivoxil among patients with chronic hepatitis B virus infection in eastern Zhejiang province].
Abstract: Prior to initiation of ART, ten percent, 3 of 29 isolates sequenced, had drug resistance mutations rtV173L, rtL180M+rtM204V and rtV214A, respectively.
Result: Three isolates had drug resistant mutations: SHH
Discussion: Even though the participants in the present study had not initiated ART, ten percent, 3 of 29 isolates sequenced, had drug resistance mutations rtV173L, rtL180M+rtM204V and rtV214A, respectively.
Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.
Result: Among patients with adefovir related resistance mutations, five had rtA181T/V, one had rtN236T and eightteen had rtV214A/E/I.
Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies.
Result: Single compensatory mutations were not detected in the switch therapy group; however, rtQ215H/P/S +- rtV214A/P mutations were found in 12 out of 88 patients (14%) in the add-on therapy group, and this difference was significant (P < 0.01).
Discussion: Further, rtQ215S and rtV214A mutations were compensatory mutations arising from ADV treatment.
Discussion: However, while the rtN236T substitution does not significantly affect sensitivity to LAM, rtA181T/V and rtQ2
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.
Abstract: Additionally, five polymorphic mutations, with a suggested role in drug resistance, were detected [rtQ215S (12.8%), rtI233V (4.3%), rtV214A (3.6%),
Abstract: Amino acid changes at other six RT positions, potentially associated with resistance, were also analyzed (rtV84M-rtV191I-rtV207L-rtV214A-rtQ215S-rtI233V).
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.
Method: We also analyzed the mutations that have been reported to possibly contribute to resistance at 10 additional positions: L82M, V84M, S85A, A194T, A200V, V214A, Q215S, I233V, P237H and NASH238TD.
[Genotype distribution of chronic hepatitis B and hepatitis C patients and investigation of the resistance patterns in hepatitis B cases].
HBV mutation literature information.
PMID: 
2013
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