Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: A total of 26 types of RT mutations, including rtS53N, rtT54N, rtL82M, rtV84M, rtS85A, rtI91L, rtY126C, rtT128I/N, rtN139D, rtW153Q, rtF166L, rt
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Discussion: Other than YMDD RT motif resistance gene mutations, the observation of co-prevalence of PC mutations and ADV resistance mutants (rtI233V, rtQ215S/Q and rtV214A) in particular in the HBeAg negative cases was in line with earlier similar reports.
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Result: At baseline, patient 4 harbored the rtA181T (1.2%), rtN236T (1.4%), and rtV214A (1.2%) substitutions, and other resistance mutations were present at low levels (<1%).
Result: At baseline, this patient harbored the rtA181T (1.2%), rtN236T (1.5%), and rtV214A (1%) substitutions, and other resistance mutations were present at low levels (<1%).
Result: Other substitutions (rtI169T/V, rtP177G,
[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
Abstract: Each of the NAs had dominant drug-resistant mutational profiles, with rtM204I+rtL180M+-rtL80I (30.9%) for LAM, rtA181T/N (21.3%), rtS213T/N (21.3%) and rtV214A (21.3%) for ADV, rtl180M (48%) for ETV, rtM204I for LdT, and rtA194T for tenofovir disoproxil fumarate (TDF).
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
Discussion: UDPS indicated that NAr mutations were pre-existent at low percentages (ranging from 0.1% to 6.7%) at baseline, including rtV173A/M, rtL180 M, rtA181 V/T, rtS202G, rtM204I/V, rtV214A, rtQ215R/H, and rtN236T mutations.
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
Result: and so did other mutations (rtN/H238T P < 0.001, rtP237H P = 0.002, and rtV214A P = 0.006).
Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates.
PMID: 25493022
2014
World journal of gastroenterology
Abstract: The most prevalent mutations were rtA181T, rtV214A, and rtN236T.
Hepatitis B and Delta virus are prevalent but often subclinical co-infections among HIV infected patients in Guinea-Bissau, West Africa: a cross-sectional study.
Discussion: The [V214A] and the [N238D] mutations may be considered as secondary resistance mutations against adefovir conferring very low-level resistance in vitro , however the clinical relevance of these HBV polymerase mutations in ART naive patients still needs to be elucidated.
Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan.
Result: In the reverse transcriptase domain of the polymerase, the following mutations were detected: rtA194T in SDAC049 (genotype D), rtV207M in SDAC020 (genotype D), rtS213T in SDAC063 and SDAC098 (genotype D), SDAC002, SDAC121 and SDAC004 (genotype E), rtV214A in SDAC059 (genotype E) and rtS215Q in SDAC049 and SDAC090 (genotype D).
ViMRT
HBV mutation literature information.
PMID: 
2018
Hepatology communications
