Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.
PMID: 34755817
2021
Revista do Instituto de Medicina Tropical de Sao Paulo
Result: One sample (1.1%) presented a compensatory mutation (rtV/F/L/M207I), which typically appears after other primary variants of resistance to LAM; and 26.7% (24/90) of the samples showed pote
Result: Strains with partial resistance mutations for ETV (rtM204V/I/S) or potentially associated with resistance to ADF (rtV214A, rtL217R, rtQ215S, rtN238T, and rtP237H) were identified in 13.9% (5/36) and 19.4% (7/36) of the samples, respectively.
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
Result: Putative resistance mutations were observed at 8 AA sites among the panel of treatment-naive patients; they were rtV191I, rtS213T, rtV214A, rtE218D, rtL229V, rtI233V, rtN238S, rtS/C256G.
Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.
Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Result: These included the previously reported mutations Discussion: This study identified several known polymerase mutations (rtL91I, rtM129L, rtW153R, rtS213T, rtV214A, rtN238T, rtN248H, and rtI269L), recorded in many previous studies (Locarnini,; Abdelnabi et al.,; Gomes-Gouvea et al.,; Zhang and Ding,; Kim et al.,; Yamani et al.,; Choi et al., 2018; Shaha et al.,; Ababneh et al.,).
Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.
Abstract: In RT, some potentially resistant substitutions such as Q215S, V191I and V214A, were revealed.
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
PMID: 31189581
2019
Journal of clinical microbiology
Result: Considering that the low sensitivity of Sanger sequencing limited the detection of NAr mutations with a low rate (<20%), 4 classical drug resistance mutations (S202C/G/I, M204I/V/S, N236T, and M250I/L/V) and 12 putative NAr mutations (V207I, S213T, V214A, Q215P/S, L217R, E218D, L229G/V/W/F, I233V, P237H, N/H238D/S/T, Y245H
Table: V214A
Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.
Abstract: None of the known tenofovir resistance mutations (M240V/I, L180M, A194T, Result: No mutations known to cause tenofovir resistance (L180M, A181I/V, A194T, M204V/I, V214A, Q215S, N236T) or lamuvudine (3TC) resistance (L80V/I, I169T, V173L, L180M, A181T, T184S, M204V/I/S, Q215S) were observed.
High frequency of drug resistance mutations in the HBV genome in ART-experienced HIV-coinfected patients in southwestern Nigeria.
HBV mutation literature information.
PMID: 
2022
Frontiers in microbiology
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