Fast and Sensitive Real-Time PCR Detection of Major Antiviral-Drug Resistance Mutations in Chronic Hepatitis B Patients by Use of a Predesigned Panel of Locked-Nucleic-Acid TaqMan Probes.
PMID: 34319801
2021
Journal of clinical microbiology
Abstract: Single-point mt for LMV and ADF resistance were detected in 57.7% and 54.1% of the
Abstract: We developed a novel real-time PCR assay that simultaneously evaluates 11 major nucleos(t)ide antiviral (NA) drug resistance mutations (mt) in chronic hepatitis B patients (CHB), including L180M, M204I/V, and V207M (lamivudine [LMV] resistance), N/H238A/T (adefovir [ADF] resistance), which are circulating in Vietnam; and T184G/L, S202I, and M250V (entecavir [ETV] resistance) and A194T (tenofovir resistance), which have been recently reported in several studies across the globe.
COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.
8Discussion: (2009) on 472 samples collected from treatment-naive American adults using conventional PCR combined Sanger DNA sequencing, 389 cases (82.4%) were found to not carry any NA-drug resistance mt, 79 cases (16.7%) were found with rtV207M, and only 4 cases (0.9%) were found with other ""putative"" mt."
Discussion: (2005) on the nonclassical rtV207M/I mt:the most frequent nonclassical mt found in treatment-naive patients:that rtV207M/I is regarded as a compensatory or secondary mt which led to suppression of the wt and predominance of the mt, possibly due to an increased replication competence.
Discussion: While our reported spectrum of mt in treatment-naive resembles that of Nguyen et al., with the majority of mt being rt
Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.
Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.
PMID: 30906435
2019
Experimental and therapeutic medicine
Discussion: Other mutations, including rtV84M, rtN118H/D/T, rtI169T, rtT184A/L/S, rtV191I, rtV207I/M, rtS213T, rtQ215P/S/H, rtI233L, rtP237H/T and rtS202G, which have been previous
[Determination of reverse transcriptase inhibitor nucleoside analogue resistance profile in pretreatment phase of patients with viral hepatitis B].
Abstract: However, potential drug resistance mutations such as rtR164R, rtG165D/A, rtG172Q, rtS176N, rtF178V, rtA181G, rtS185N/G/C, rtV207M, rtQ215H/S, rtL231V, rtI233K, rt
Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.
Result: In this study, non-classical mutations were observed in 29 patients who suffering from virological breakthrough and without classical mutations (Table 4) at 9 sites (V191I, V207I/M, S213T, E218D, F221Y, I224V, L229V, N/H238 and R242D).
Result: Out of 24 mutations of L229 (Table 3), 18 were associated to M204I or V; 2 coexisted with F221Y (Table 4); 2 were associated to A181T; 2 were associated to V207M (Table 4) and N236V, respectively.
Result: These sites could be classified into the following groups: PMID: 31189581
2019
Journal of clinical microbiology
Table: V207M
Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.
Discussion: The reverse transcriptase mutations rtA194T, rtV207M, rtS213T, rtV214A and rtS215Q detected in the present study are neither primary resistance mutations, nor have they ever been seen in overt resistance during therapy.
Discussion: When mutations rtA194T, rtV207M rtS213T rtV214A and
HBV mutation literature information.
PMID: 
2022
Frontiers in microbiology
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