Result: Patient 19 harbored the LVDr substitutions rtL180M+rtM204V with either rtV173L or rtV207I while Pt20 harbored the LVDr substitutions rt
Result: Phenotypic analysis of recombinant clones from these patients showed reduced susceptibility to ETV (3.8-fold to 6.3-fold greater than WT; Table 4) similar to LVDr HBV, suggesting that the LVDr-associated compensatory substitutions rtV173L, rtV207I, and rtL229L/W did not impact ETVr.
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: A total of 26 types of RT mutations, including rtS53N, rtT54N, rtL82M, rtV84M, rtS85A, rtI91L, rtY126C, rtT128I/N, rtN139D, rtW153Q, rt Table: V207I
Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.
Result: Second, at ETV VBK, rtI169T and/or rtS202G, which are typically associated with ETV resistance, always appeared linked to the LMV resistance signature (rtL180M-rtM204V), in keeping with previous reports (Table 5), whereas rtV207I, which has not been previously associated with ETV resistance, unexpectedly appeared in most of the highly frequent combinations and always together with other variants, especially rtM204V (Table 5).
Table: V207I
Discussion: However, in contrast to this hypothesis, the sensitivity of the LMV-re
Long-term monitoring drug resistance by ultra-deep pyrosequencing in a chronic hepatitis B virus (HBV)-infected patient exposed to several unsuccessful therapy schemes.
Abstract: CONCLUSIONS: In the patients with suboptimal viral response to ADV therapy after LAM resistance, the ADV resistance mutation patterns of A181T+N236T, A181V and A181T could easily be selected during ADV monotherapy; while in the patients with combination therapy, the LAM resistance mutation patterns of M204V
Abstract: The LAM resistance mutation patterns of M204V+L180M, M204V+L180M+L229V, M204I+L80I, M204V+L180M+V207I were detected in the combination therapy group.
Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case.
Discussion: Resistance-associated mutations outside the YMDD motiv include amino acid exchanges at the reverse transcriptase codon L180 M (rtL180M) or the rtV207I codon.
[Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].
Abstract: RESULTS: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12 samples (25.53%,12/47), correlating with T126A, I126T/S, P127T, T131N, M133L, M133T and T140I; high proportion of mutation clustered in first loop of 'a' determinant (92.86%,13/14), rtV207I mutation in C domain of reverse transcription occured in one sample.
HBV mutation literature information.
PMID: 
2018
Zhonghua gan zang bing za zhi
Browser Board
Co-occurred Entities
Filtrator
ViMRT