Abstract: Primary drug resistance mutations (rtV173L + rtL180M + rtM204V) to lamivudine and telbivudine and a compensatory mutation (rtQ215H) to lamivudine and adefovir were described in the HBV pol gene sequence.
Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.
Introduction: Although rtQ267H only led to slight resistance to LMV and LdT, enhanced HBV replication, aggravated existing LMV-resistance, and was proved to be another adaptive mutation of LMV, except rtL180M and rtV173L.
Introduction: The most common resistance mutations to LMV and LdT are rtM204I/V, located at the YMDD motif within the C domain of RT, usually accompanied with compensatory mutations of rtL180M and/or rtV173L to restore HBV replication capacity.
Discussion: Due to select
Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants.
Introduction: Other mutations that have been reported to be associated with lamivudine resistance include rtA181V/T and several secondary RT mutations, for example, rtV173L and rtL180M.
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome.
3Introduction: The region analyzed extends from codon rt148 to rt208 in the P ORF, which includes most RT codons corresponding to reported relevant NA-resistant aa substitutions (rtI169T, rtV173L, rtL180M, rtA181T/V, rtT184S/A/I/L/G/C/M, rtA194T, rtA202C/G/I, rt PMID: 22672436
2012
BMC microbiology
Introduction: Compensatory mutations in the rt domain (rtL180M, rtV173L, rtL80I/V) that partially restore replication efficiency are often co-selected in HBV rt204 mutants.
Long-term hepatitis B virus (HBV) response to lamivudine-containing highly active antiretroviral therapy in HIV-HBV co-infected patients in Thailand.
Abstract: HBV breakthrough was observed only in HBeAg-positive patients and 6 of 7 patients presenting HBV breakthrough had the rtM204I/V mutations associated with 3TC resistance along with rtL180M and/or rtV173L.
Result: In the
Discussion: Over the 5 years of follow-up, 6 of 7 patients presenting HBV breakthrough had the rtM204I (due to the ntG741A uncommon mutation) or M204V mutations associated with 3TC resistance along with rtL180M and/or rtV173L.
Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.
Result: Among patients with lamivudine related resistance mutations, eleven had rtM204I/V/S (four with rtM204I, six with rtM204V and one with rtM204S), nine had rtL180M and three had rtV173L mutation.
Result: Eight patients had double mutations of rtM204V/I+rtL180M and one patient with triple mutations of rtM204V+
Clinical characteristics and chronicity of acute hepatitis B induced by lamivudine-resistant strains.
Abstract: Among these patients, six harbored the rtM204I mutation, two harbored the rtL180M + rtM204I mutations, one harbored the rtM204I + rtM204V mutations, one harbored the rtL80I + rtM204I mutations, and one harbored the rtV173L + rtL180M + rtM204V mutations.
HBV mutation literature information.
PMID: 
2013
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