Method: As previously described, we used the Mutation Reporter Tool (MRT) software (http://hvdr.bioinf.wits.ac.za/mrt/) to look for HBV resistance-associated mutations (RAMs) in the Polymerase catalytic domain represented by major RAMs (A181T/V/S, A194T, M204V/I/S and N236T) and compensatory RAMs (I169T, V173L, L180M, S202G/I and M250V.
Result: The analysis of HBV strains for the S/Pol gene by the MRT online software showed that of the major RAMs, M204V/I was the most frequent (4/10, 40%), followed by it
HBV Drug Resistance Substitutions Existed before the Clinical Approval of Nucleos(t)ide Analogues: A Bioinformatic Analysis by GenBank Data Mining.
Introduction: According to several clinical practice guidelines and authoritative reviews, NUCr substitutions can be classified into two categories: primary NUCr substitutions at 8 codons ( Discussion: In conclusion, we confirmed the presence of naturally occurring typical NUCr substitutions of rtL80V, rtV173L and rtT184A/S with low frequencies before the clinical approval of NUCs.
Discussion: Substitutions rtL80V (n = 7) or rtV173L (n = 2) are typical secondary substitutions that can restore functional defects of HBV polymerase caused by primary LAM or LdT resistance substitutions.
HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
Discussion: In our study, twenty (95.2%) of the 21 patients had at least one mutation that may confer clinical resistance to both telbivudine (rtM204V/I) and 3TC (rt180M + rtM204V/I, rtV173L + rtL180M + rtM204V/I, and rtL80I + rtM204I).
Abstract: Lamivudine selected DRMs, that is, rtL180M (29.3%) and rtM204V/I (29.3%) and rtV173L (15.5%) were more prevalent in HBV-HIV-coinfected individuals but absent in HBV-monoinfected individuals.
Abstract: RESULTS: In 34 out of 161 study subjects (21.1%) HBV drug resistance mutations (DRMs) were detected with a frequency of 3.1% rtL80F/I, 0.6% rtA181V, 1.2% rtT184S, 6.2% rtV173L, 10.6%
Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010-2014).
PMID: 28017671
2017
Journal of global antimicrobial resistance
Abstract: M204I, N236T and L180M+M204V+V173L/S202G were the most common substitutions for l-nucleoside (3TC and LdT), ADV and ETV genotypic resistant phenotypes, respectively.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Introduction: Primary LMV resistance mutation has been mapped in the reverse transcriptase (RT) domain of HBV Pol and typically involved rtM204I/V, while compensatory mutations rtL180M, rtV173L, and rtL80I are often co-selected during therapy to restore HBV replication efficacy.
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Discussion: The presence of rtS78T in addition to rtT184S, rtV173L, rtL180M, and rtM204V, was associated with a two-fold reduction in ETV susceptibility; however, in line with our results, the ETV resistance level for this mutation alone did not exceed 1.8-fold of the level of wild type HBV.
The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia.
Abstract: All HIV/HBV positive cases were on ART with anti-HBV activity (i.e., 3TC) and 3TC associated HBV DRMs (i.e., rtV173L, rtL180M, and rtM204V) were detected in 7/13 (53.8%) subjects.
Result: rtV173L, rtL180M
Table: V173L
Discussion: We found that more than half of these patients, for whom sequence data were available, had 3TC selected DRMs (rtV173L, rtL180M, and rtM204V).
Predominance of Hepatitis B Virus Genotype A Among Treated HIV Infected Patients Experiencing High Hepatitis B Virus Drug Resistance in Nairobi, Kenya.
PMID: 28316253
2017
AIDS research and human retroviruses
Abstract: Five subjects had rtV173L, rtL180M, and rtM204V and one with rtL180M and rtM204V major mutations.
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Discussion: The most prevalent mutations in RT region of the study isolates was Q149K (9.83%) followed by N118D/T (6.55%), L157M (4.91%) and H124Y, A113Y/S, N131D/S, L145M, V173A/L, 3.27% for each one.
Discussion: The well known mutation rtV173L observed in two cases (3.2%), which is a compensatory mutation and could be selected in lamivudine-resistant patients due to an enhanced replication phenotype.
HBV mutation literature information.
PMID: 
2018
PloS one
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