Low-level persistence of drug resistance mutations in hepatitis B virus-infected subjects with a past history of Lamivudine treatment.
PMID: 23114756
2013
Antimicrobial agents and chemotherapy
Abstract: UDPS detected >=1 LAM resistance mutations (rtL80I/V, rtV173L, rtL180M, rtA181T, and rtM204I/V) in 10 (22%) of the 46 LAM-experienced subjects, including 5 in whom LAM resistance mutations were not identified by Sanger sequencing.
High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.
Abstract: Both mutations, especially mutation rtM204V, were most often accompanied by compensatory mutations rtV173L and rtL180M but also by mutations conferring entecavir (n = 5) or adefovir resistance (n = 4).
Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population.
Abstract: Notably, classical antiviral resistance mutations (rtL80I/V-rtI169T-rtV173L-rtL180M-rtA181T/V/S-rtT184A/S/G/C-rtA194T-rtS202C /G/I -rtM204V/I-rtN236T-rtM250V) were n
Combination of allele-specific detection techniques to quantify minority resistance variants in hepatitis B infection: a novel approach.
PMID: 23454647
2013
Journal of virological methods
Discussion: In summary, the allele-specific quantitative PCR described here, which uses a combination of locked nucleic acid primers and a minor groove binder probe, is a highly sensitive, specific, rapid, and inexpensive method for directly measuring minor viral quasispecies of the triple combination mutation rtV173L+rtL180M+rtM204V within one HBV genome.
Discussion: locked nucleic acids (LNAs) and minor groove binders (MGBs), was utilized to increase the specificity of detection of the triple mutation rtV173L+rtL180M+rtM204V in HBV polymerase
Virology and clinical sequelae of long-term antiviral therapy in a North American cohort of hepatitis B virus (HBV)/human immunodeficiency virus type 1 (HIV-1) co-infected patients.
Abstract: Anti-HBV drug resistant mutations were detected in 54% (6/11) (i.e., any combination of rtV173L, rtL180M, M204V) and 45% (5/11) had an immune escape mutation (sP120S).
Virological response and antiviral resistance mutations in chronic hepatitis B subjects experiencing entecavir therapy: an Indian subcontinent perspective.
Result: rtV173L, rtL180M, rtA181V/T, rtT184G, rtS202I, rtM204V/I, rtN236T and rtM250V were first studied and then, others residues with changes present in at least two patients were further considered.
Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.
Discussion: Other compensatory mutations include the rtV173L and rtL80I changes.
[Low prevalence of hepatitis B virus primary drug resistance in Southern Spain].
PMID: 23602529
2013
Enfermedades infecciosas y microbiologia clinica
Abstract: RESULTS: rtV173L, a lamivudine compensatory mutation, was detected in two patients (1.9%), rtI233V in one patient, and another one carried the sG145R vaccine escape mutation.
Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B.
Abstract: L80I and V173L were also identified in patient 6.
Abstract: Patient 4 had mutations at T128N (1%), I169L (1%), V173L (2%), A181V (1%), and Q215H (1%).
Abstract: RESULTS: Among the six patients with LAM failure, the analysis of 100 clones from patient 1 revealed the substitutions L180M in 1% of clones and V173L in 2% of clones.
Result: In patient 1, changes of the P gene, rtW153Q, rtI169L, rtV173L,
HBV mutation literature information.
PMID: 
2013
Antimicrobial agents and chemotherapy
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