Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naive and lamivudine-treated patients with chronic hepatitis B.
Abstract: With little influence on immune escape-associated mutation frequencies within 'a' determinant, LMV-monotherapy significantly induced classical LMVr-associated mirror changes sE164D/rtV173L, sI195M/rtM204V and sW196L/S/rtM204I, as well as non-classical ones sG44E/rtS53N, sT47K/A/rt
Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers.
Introduction: Compensatory mutations rtL180M, rtV173L, and rtL80I to LAM
Result: Clonal sequencing (44 clones) of the sample at this point (Sc2) showed predominance of rtM204Q strain (52%) concomitant with rtL180M+A181V (16%), rtA181T (16%), rtV173L+L180M+A181V (9%), rtA181V (5%) and wild-type (2%) strains in the viral pool.
Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
Discussion: successfully developed an allele-specific quantitative PCR with combination of locked nucleic acid primers and a minor groove binder probe for the quantitative determination of minor viral quasispecies of the triple combination mutation rtV173L+rtL180M+rtM204V within one HBV genome.
Analysis of complete nucleotide sequences of Angolan hepatitis B virus isolates reveals the existence of a separate lineage within genotype E.
Result: The two others, LDA173 and LDA339, displayed the lamivudine resistance triple mutation rtV173L, rtL180M, rtM204V/I which causes the concomitant amino acid substitutions E164D/G and I195M in the small S protein (Table 3).
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Introduction: For example, resistance to lamivudine and telbivudine is conferred by mutation rtM204V or rtM204I in the YMDD motif, and this is often associated with compensatory mutations rtL180M and/or rtV173L restoring a higher replication capacity.
Result: It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rt PMID: 24637457
2014
PloS one
Table: V173L
Establishment of drug-resistant HBV small-animal models by hydrodynamic injection.
Method: For their generations, rtL180M, rtM204V and rtV173L mutations were introduced into pTmcs-HBV1.3 by site-mutagenesis with the appropriate primers using QuickChange Lightning Site-Directed Mutagenesis Kit (Agilent Technologies) as per the manufacturer s recommendations.
Method: In brief, a total of 13.5 mug of pTmcs-HBV1.3, pTmcs-HBV1.3-3TCR or pTmcs-HBV1.3-3TCR-V173L and 4.5 mug of pCMV-SB were co-injected into the tail vein of 6- to 9-week-old NOD/SCID mice in a volume of saline equivalent to 8% of the mouse body weight (e.g., 1.6 mL for mouse of 20 g).
Method: pTmcs-HBV1.3-3TCR and pTmcs-HBV1.3-3TCR-V173L are two different lamivudine-resistant mutants carrying
Analysis of reverse transcriptase gene mutations in the hepatitis B virus at a university hospital in Korea.
Result: When the rtM204V and rtM204I mutation groups were compared, all 72 cases of rtM204V mutation had a simultaneous rtL180M mutation, while in 79 cases of rtM204I mutation, 43 cases (54.4%) had a simultaneous rtL180M mutation, 33 cases (41.8%) had the rtM204I mutation alone, and the remaining 3 cases (3.8%) showed a simultaneous rtV173L mutation.
Hepatitis B and Delta virus are prevalent but often subclinical co-infections among HIV infected patients in Guinea-Bissau, West Africa: a cross-sectional study.
HBV mutation literature information.
PMID: 
2014
Antiviral research
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