Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
PMID: 31189581
2019
Journal of clinical microbiology
Introduction: For instance, M204V/I in RT (rtM204V/I) is a classical lamivudine (LMV) resistance mutation, which also greatly reduces susceptibility to telbivudine (LdT); rtA181T/V is not only reported as an adefovir dipivoxil (ADV) resistance mutation, but rtA181T/V also confers a decreased susceptibility to LMV, LdT, tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF); rtM204V/I and rtL180M together with rtI169T, rt PMID: 31566576
2019
Antiviral therapy
Abstract: HBV polymerase amino acid substitutions found included rtV173L, rtL180M, rtM204V, rtK212R, rtS213T, rtV214A, rtL229V and rtP237A/S.
Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.
PMID: 31880877
2019
Polish journal of microbiology
Discussion: In the current study, we detected rtV173M partial resistance mutation in one patient according to Geno2pheno Drug Resistance Program, however, the rtV173L substitution has been reported more commonly in the literature.
Discussion: LAM-associated resistance triple mutation pattern (rtV173L + rtL180M + rtM204V) has also been shown to enhance viral replication compared with rtL180M + rtM204V.
Discussion: Sayan has shown in one of his studies that rt
Comparison of replication competence of wild-type and lamivudine-resistant hepatitis B virus isolates from a chronic hepatitis B patient.
Abstract: Sequencing reverse transcriptase region of HBV revealed that the patient developed lamivudine-resistant mutations (rtV173 L, rtL180 M, and rtM204 V) 36 months after the start of lamivudine therapy, and lamivudine-resistant mutants reversed to wild-type after the treatment was stopped for 8 months.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: As previously described, we used the Mutation Reporter Tool (MRT) software (http://hvdr.bioinf.wits.ac.za/mrt/) to look for HBV resistance-associated mutations (RAMs) in the Polymerase catalytic domain represented by major RAMs (A181T/V/S, A194T, M204V/I/S and N236T) and compensatory RAMs (I169T, V173L, L180M, S202G/I and M250V.
Result: The analysis of HBV strains for the S/Pol gene by the MRT online software showed that of the major RAMs, M204V/I was the most frequent (4/10, 40%), followed by it
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Method: In particular, the HBV-HIV co-infected group was characterized by the YMDD RT associated 3TC/ETV drug resistance gene mutations (rtM204V/I) which appeared as multiple combinations with ot
Table: V173L
Discussion: Moreover, with a proportional HBeAg positive and negative status, 29.3% of HIV co-infected patients included in the current study were reported to have 3TC/ETV resistance due to rtM204V/I+rtL180M+rtV173L mutant gene variants.
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: Another compensatory RT mutation, rtV173L, was also detected in several studies of treatment-naive patients, where Zheng et al, Wang et al, and Mirandola et al reported that it occurred in 0.6%, 0.56%, and 0.39% of their patients, respectively.
Method: Our literature based incidence data showed that rtL180M had the highest natural incidence (2.96%), which was higher than the pooled mutation rate of rtL80I/V and V173L (incidence:0.46% and 0.15%, respectively) (Figure 1).
Method: The mutations rtL80I/V, rtV173L, rt
[Monitoring by high-sensitivity HBV DNA assay during treatment in chronic hepatitis B e antigen negative patients].
Abstract: We also identified the suite of mutations rtM204V/I + rtL180M + rtV173L, that has been associated with vaccine escape, in over 1/3 of cohorts.
Result: Overall, the most prevalent RAM was rtM204V/I in both treatment experienced and treatment naive individuals, and occurring either alone or in combination with other polymorphisms rtL80I/V, rtV173L, rtL180M, rtA181S, rt
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.
Result: One patient (Pt21) harbored the novel substitution rtC188L with the LVDr-associated compensatory substitution rtV173L.
Result: Patient 19 harbored the LVDr substitutions rtL180M+rtM204V with either rtV173L or rtV207I while Pt20 harbored the LVDr substitutions rtL180M+rtM204V with either rtL229V
HBV mutation literature information.
PMID: 
2019
Journal of clinical microbiology
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