literature

HBV mutation literature information.

Hepatitis B Virus Genotypes and Antiviral Resistance Mutations in Romanian HIV-HBV Co-Infected Patients.

PMID: 35454370 2022 Medicina (Kaunas, Lithuania)

Result: M204V/I: 48.8%, plus L180M: 33.3% +- L80V: 28.8% and V173L: 42.2%:a profile suggestive for LAM resistance (with all mutations, except for M204V, also being associated with telbivudine resistance, and the combination of L180M, M204V, andV173L being associated with entecavir (ETV) resistance.

Discussion: In our study, despite the frequent association of the primary resistance mutations M204V/I with the compensatory L180M, V173L, and L80V/I mutations, lamivudine-resistant HBV strains tend to be associated with lower viral loads compared to wild-type strains; further characterization of t

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Table: V173L

Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.

PMID: 35214692 2022 Vaccines

Introduction: In contrast, the HBV variant with three mutations in the polymerase gene (rtV173L + rtL180M + rtM204V), also generating the G145R mutation in S-HBsAg due to overlapping reading frames, was stable.

Hepatitis B virus genetic multiplicity and the associated HBV lamivudine resistance mutations in HBV/HIV co-infection in Western Kenya: A review article.

PMID: 34954390 2022 Infection, genetics and evolution

Abstract: HBV polymerase rtV173L, rtL180M, and rtM204V major substitutional mutations were identified.

Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.

PMID: 33562603 2021 International journal of molecular sciences

Method: Two clones (CYEI: rtS106C (C) + rtH126Y (Y) + rtD134E (E) + rtL269I (I) and CYELMVI: rtS106C (C) + rtH126Y (Y) + rtD134E (E) + rtV173L (L) + rtL180M (M) + rt204V (V) + rtL269I (I)) have been described in our previous study.

Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.

PMID: 33446224 2021 Virology journal

Abstract: HBV DRMs V173L, L180M, S202I and M204V/I, which are associated with lamivudine resistance, were detected in 32.2% (n = 10/31) of the HBV DNA-positive samples.

Result: Amino acid substitutions were detected in the following frequency: rtM204V/I (9/31; 29.0%), rtL180M (8/31; 25.8%), rtV173L (7/31; 22.5%).

Result: No single mutation was detected while all amino acid substitutions were detected in combinations as rtL180M + rtV173L + rt

The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report.

PMID: 33758517 2021 Infection and drug resistance

Discussion: Three mutations associated with LAM resistance have been mostly described: rtM204V/I in C domain, rtV173L and rtL180M in B domain.

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Result: RAMs L80I/M/V, V173L, L180M, A181T/V and T184X are common to 3TC, ETV and/or TFV.

Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, M204I/V, L217R, L229V/W and I269L) and eight VEMs (C139S, S/T140I,

Hepatitis B virus genetic heterogeneity and drug resistance among jaundiced patients at Coast General Teaching and Referral Hospital, Mombasa County, Kenya.

PMID: 34234632 2021 International journal of health sciences

Result: Mutation rtM204V conferring resistance to 3CT occurred predominantly at 26.7% in all the patients followed by rtL180M (20.0%) and rtV173L at 13.3%.

Result: On the other hand, 5 patients (11.1%) had rtM204V mutations with rtV173L and rtL180M secondary mutations [Table 2].

Result: Six patients (13.3%) had rtV173L multiple mutations at rtM204V with rtL1

High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.

PMID: 33986897 2021 The Canadian journal of infectious diseases & medical microbiology

Result: However, rtI169 T, rtA194 T, rtV173 L, rtL180 M, rtL82 M, rtS85 A, rtV207I, rtL217 R, and rtS/C256G mutations were not present before TBV treatment.

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